EDNRB and GNA13

Number of citations of the paper that reports this interaction (PMID 12135322)
2

Data Source:
HPRD (in vivo)

		EDNRB	GNA13
Gene Name		endothelin receptor type B	guanine nucleotide binding protein (G protein), alpha 13
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane Membrane Raft	Nucleus Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 1 Angiotensin Receptor Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of PH Cell Surface Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Aging Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Negative Regulation Of Neuron Maturation Response To Organic Cyclic Compound Vein Smooth Muscle Contraction Sensory Perception Of Pain CGMP-mediated Signaling Melanocyte Differentiation Regulation Of Fever Generation Negative Regulation Of Cellular Protein Metabolic Process Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Cellular Response To Lipopolysaccharide Endothelin Receptor Signaling Pathway	Patterning Of Blood Vessels In Utero Embryonic Development Movement Of Cell Or Subcellular Component Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Cell Differentiation Platelet Activation Regulation Of Cell Migration Activation Of Phospholipase D Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling Thromboxane signalling through TP receptor G alpha (12/13) signalling events Signal amplification Platelet activation, signaling and aggregation
Drugs		Bosentan Sitaxentan
Diseases
GWAS		Hair color ( 23548203) Total ventricular volume ( 21116278)
Protein-Protein Interactions		7 interactors: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 NOS3	31 interactors: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR
Entrez ID		1910	10672
HPRD ID		08834	05100
Ensembl ID		ENSG00000136160	ENSG00000120063
Uniprot IDs		P24530	B7Z7R0 F5H1G8 Q14344
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Contraction Vasoconstriction Regulation Of Body Fluid Levels Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Potassium Ion Transport Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Blood Circulation Regulation Of Oxidoreductase Activity Angiogenesis Regulation Of The Force Of Heart Contraction By Chemical Signal Cardiovascular System Development Regulation Of Systemic Arterial Blood Pressure Regulation Of Blood Coagulation Cellular Metal Ion Homeostasis Blood Coagulation Blood Vessel Morphogenesis Hemostasis Reactive Oxygen Species Metabolic Process Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Wound Healing Vascular Smooth Muscle Contraction Blood Vessel Development Second-messenger-mediated Signaling Cellular Chemical Homeostasis Vasculature Development Ion Homeostasis Inositol Phosphate-mediated Signaling Wound Healing Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Ion Transport Positive Regulation Of Heart Rate Negative Regulation Of Potassium Ion Transport Regulation Of Developmental Pigmentation Positive Regulation Of Ion Transport Positive Regulation Of Catalytic Activity Regulation Of Cellular Component Movement Cellular Homeostasis Response To Wounding Nitric Oxide Metabolic Process Signal Transduction Positive Regulation Of Heart Contraction	Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Catalytic Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Signaling Regulation Of Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Stimulus Cytosolic Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Activation Cellular Chemical Homeostasis Ion Homeostasis Apoptotic Process Programmed Cell Death Response To Stimulus Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Cell Death Death Chemical Homeostasis Cellular Homeostasis Regulation Of Cellular Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Platelet Activation Homeostatic Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Cellular Metabolic Process Termination Of Signal Transduction
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded
Tagcloud (Intersection) ?