EDNRB and EDN3

Number of citations: 0 (PubMedID 11982704)
Data Source: HPRD (in vivo)

		EDNRB	EDN3
Name		endothelin receptor type B	endothelin 3
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Nuclear Membrane	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding	Signaling Receptor Binding Hormone Activity Endothelin B Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Renin Secretion Into Blood Stream Regulation Of Heart Rate Regulation Of PH Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Gene Expression Negative Regulation Of Neuron Maturation Vein Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Heparin Proteoglycan Metabolic Process Melanocyte Differentiation Regulation Of Fever Generation Aldosterone Metabolic Process Response To Lipopolysaccharide Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Developmental Pigmentation Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Sodium Ion Homeostasis Canonical Wnt Signaling Pathway Positive Regulation Of Penile Erection Establishment Of Endothelial Barrier Renal Sodium Ion Absorption Calcium Ion Transmembrane Transport Cellular Response To Lipopolysaccharide Protein Transmembrane Transport Podocyte Differentiation Endothelin Receptor Signaling Pathway Renal Albumin Absorption Neuroblast Migration Chordate Pharynx Development Response To Sodium Phosphate Response To Endothelin	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Blood Circulation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Gene Expression Intracellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Regulation Of Cell Migration Neutrophil Chemotaxis Neuron Projection Development Vasoconstriction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Regulation Of Developmental Pigmentation Axon Extension Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Blood Vessel Diameter Maintenance Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Bosentan IRL-1620 Sitaxentan Ambrisentan Enrasentan Tezosentan Macitentan	None
Diseases		Hirschsprung disease (HD) Waardenburg syndrome (WS) ABCD syndrome Nasopharyngeal cancer	Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD) Waardenburg syndrome (WS)
GWAS		Appendicular lean mass ( 33097823 ) Craniofacial microsomia ( 26853712 ) Hair color ( 23548203 29662168 ) Total ventricular volume (Alzheimer's disease interaction) ( 21116278 )	Blood pressure ( 21909110 ) Diastolic blood pressure ( 21909115 27618452 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Hypertension ( 19430479 21909115 ) Metabolite levels ( 23823483 ) Response to diuretic therapy in hypertension ( 23753411 ) Systolic blood pressure ( 21909115 27618447 27618452 28739976 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 )
Interacting Genes		7 interacting genes: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 NOS3	5 interacting genes: CMA1 CTSE EDNRA EDNRB KEL
Entrez ID		1910	1908
HPRD ID		08834	00570
Ensembl ID		ENSG00000136160	ENSG00000124205
Uniprot IDs		P24530	P14138 Q4FAT2
PDB IDs		5GLH 5GLI 5X93 5XPR 6IGK 6IGL 6LRY 8HBD 8HCX 8IY5 8IY6 8XGR 8XVE 8XVH 8XWP 8XWQ 8ZRT	6IGK
GO Terms Enriched among Interactors		Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Blood Vessel Diameter Maintenance Vasoconstriction Regulation Of Tube Size Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure Vein Smooth Muscle Contraction Regulation Of Heart Contraction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Muscle System Process Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Blood Circulation Regulation Of Blood Coagulation Vascular Process In Circulatory System Regulation Of Hemostasis Regulation Of Potassium Ion Transport Regulation Of Developmental Process Circulatory System Process Artery Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Tonic Smooth Muscle Contraction Regulation Of Heart Rate Endothelin Receptor Signaling Pathway Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Vascular Associated Smooth Muscle Contraction Guanyl Nucleotide Binding Regulation Of Wound Healing Regulation Of Cell Migration Positive Regulation Of Hormone Secretion Regulation Of Cell Motility Nitric Oxide Biosynthetic Process G-protein Beta/gamma-subunit Complex Binding Regulation Of Muscle Contraction Regulation Of Response To Wounding Regulation Of The Force Of Heart Contraction Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Migration Regulation Of System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Negative Regulation Of Potassium Ion Transport Positive Regulation Of Cell Motility Nitric Oxide Metabolic Process Positive Regulation Of Smooth Muscle Contraction	Vasoconstriction Endothelin Receptor Activity Renal Albumin Absorption Neural Crest Cell Migration Mesenchymal Cell Migration Renal Protein Absorption Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Developmental Pigmentation Ameboidal-type Cell Migration Blood Vessel Diameter Maintenance Regulation Of Tube Size Vascular Associated Smooth Muscle Contraction Renal Sodium Ion Absorption Renal Sodium Ion Transport Cell Differentiation Involved In Kidney Development Sodium Ion Homeostasis Establishment Of Endothelial Barrier Vascular Process In Circulatory System Chemical Homeostasis Endothelial Cell Development Renal Absorption Pigmentation Circulatory System Process Smooth Muscle Contraction Inorganic Ion Homeostasis Protein Transmembrane Transport Peptidase Activity Enteric Smooth Muscle Cell Differentiation Proteoglycan Metabolic Process Monoatomic Cation Homeostasis Homeostatic Process Monoatomic Ion Homeostasis Muscle Cell Development Canonical Wnt Signaling Pathway Regulation Of Heart Rate Intracellular Chemical Homeostasis Renal System Process Podocyte Apoptotic Process Cellular Response To Human Chorionic Gonadotropin Stimulus Posterior Midgut Development Extracellular Matrix Of Synaptic Cleft Protein Metabolic Process Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metal Ion Transport Cellular Homeostasis Basement Membrane Disassembly Semaphorin-plexin Signaling Pathway Involved In Axon Guidance