EDNRB and GNA11

Number of citations of the paper that reports this interaction (PubMedID 10789830)
34

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EDNRB	GNA11
Description		endothelin receptor type B	G protein subunit alpha 11
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GO Annotations	Cellular Component	Plasma Membrane Membrane Nuclear Membrane	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Renin Secretion Into Blood Stream Regulation Of Heart Rate Regulation Of PH Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Gene Expression Negative Regulation Of Neuron Maturation Vein Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Heparin Proteoglycan Metabolic Process Melanocyte Differentiation Regulation Of Fever Generation Aldosterone Metabolic Process Response To Lipopolysaccharide Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Developmental Pigmentation Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Sodium Ion Homeostasis Canonical Wnt Signaling Pathway Positive Regulation Of Penile Erection Establishment Of Endothelial Barrier Renal Sodium Ion Absorption Calcium Ion Transmembrane Transport Cellular Response To Lipopolysaccharide Protein Transmembrane Transport Podocyte Differentiation Endothelin Receptor Signaling Pathway Renal Albumin Absorption Neuroblast Migration Chordate Pharynx Development Response To Sodium Phosphate Response To Endothelin	Skeletal System Development Action Potential Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Heart Development Phototransduction, Visible Light Regulation Of Blood Pressure Entrainment Of Circadian Clock Positive Regulation Of Insulin Secretion Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH Endothelin Receptor Signaling Pathway Cranial Skeletal System Development Ligand-gated Ion Channel Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Bosentan IRL-1620 Sitaxentan Ambrisentan Enrasentan Tezosentan Macitentan
Diseases		Hirschsprung disease (HD) Waardenburg syndrome (WS) ABCD syndrome Nasopharyngeal cancer
GWAS		Appendicular lean mass ( 33097823) Craniofacial microsomia ( 26853712) Hair color ( 23548203 29662168) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)	Asthma ( 31959851)
Interacting Genes		7 interacting genes: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 NOS3	17 interacting genes: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A NHERF1 PTGIR RGS14 RGS3 TBXA2R TRPC3 TSHR
Entrez ID		1910	2767
HPRD ID		08834	00759
Ensembl ID		ENSG00000136160	ENSG00000088256
Uniprot IDs		P24530	P29992
PDB IDs		5GLH 5GLI 5X93 5XPR 6IGK 6IGL 6LRY 8HBD 8HCX 8IY5 8IY6 8XGR 8XVE 8XVH 8XWP 8XWQ 8ZRT	6OIJ 7RKF 7TRY 7XXH
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Blood Vessel Diameter Maintenance Vasoconstriction Regulation Of Tube Size Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure Vein Smooth Muscle Contraction Regulation Of Heart Contraction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Muscle System Process Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Blood Circulation Regulation Of Blood Coagulation Vascular Process In Circulatory System Regulation Of Hemostasis Regulation Of Potassium Ion Transport Regulation Of Developmental Process Circulatory System Process Artery Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Tonic Smooth Muscle Contraction Regulation Of Heart Rate Endothelin Receptor Signaling Pathway Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Vascular Associated Smooth Muscle Contraction Guanyl Nucleotide Binding Regulation Of Wound Healing Regulation Of Cell Migration Positive Regulation Of Hormone Secretion Regulation Of Cell Motility Nitric Oxide Biosynthetic Process G-protein Beta/gamma-subunit Complex Binding Regulation Of Muscle Contraction Regulation Of Response To Wounding Regulation Of The Force Of Heart Contraction Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Migration Regulation Of System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Negative Regulation Of Potassium Ion Transport Positive Regulation Of Cell Motility Nitric Oxide Metabolic Process Positive Regulation Of Smooth Muscle Contraction	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Smooth Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Vascular Process In Circulatory System Circulatory System Process G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Signal Transduction Vasoconstriction Plasma Membrane Muscle Contraction Regulation Of Blood Circulation Muscle System Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Inorganic Ion Homeostasis Membrane System Process Regulation Of Vasoconstriction Vascular Associated Smooth Muscle Contraction Regulation Of Cell Communication Regulation Of Signaling Endothelin Receptor Activity Calcium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of MAPK Cascade Calcium Ion Homeostasis Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Calcium Ion Transport Regulation Of Muscle System Process Regulation Of Intracellular Signal Transduction Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Renal Albumin Absorption G Protein-coupled Serotonin Receptor Complex Regulation Of ERK1 And ERK2 Cascade Ameboidal-type Cell Migration Positive Regulation Of Multicellular Organismal Process Type 1 Angiotensin Receptor Binding Chemical Homeostasis Renal Absorption
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