EDNRB and GRK6

Number of citations of the paper that reports this interaction (PMID 9211925)
37

Data Source:
HPRD (in vitro)

		EDNRB	GRK6
Gene Name		endothelin receptor type B	G protein-coupled receptor kinase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane Membrane Raft	Membrane
	Molecular Function	Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding	G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of PH Cell Surface Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Aging Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Negative Regulation Of Neuron Maturation Response To Organic Cyclic Compound Vein Smooth Muscle Contraction Sensory Perception Of Pain CGMP-mediated Signaling Melanocyte Differentiation Regulation Of Fever Generation Negative Regulation Of Cellular Protein Metabolic Process Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Cellular Response To Lipopolysaccharide Endothelin Receptor Signaling Pathway	Protein Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Bosentan Sitaxentan
Diseases
GWAS		Hair color ( 23548203) Total ventricular volume ( 21116278)	Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Metabolite levels ( 22916037)
Protein-Protein Interactions		7 interactors: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 NOS3	18 interactors: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R
Entrez ID		1910	2870
HPRD ID		08834	02925
Ensembl ID		ENSG00000136160	ENSG00000198055
Uniprot IDs		P24530	P43250
PDB IDs			2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Contraction Vasoconstriction Regulation Of Body Fluid Levels Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Potassium Ion Transport Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Blood Circulation Regulation Of Oxidoreductase Activity Angiogenesis Regulation Of The Force Of Heart Contraction By Chemical Signal Cardiovascular System Development Regulation Of Systemic Arterial Blood Pressure Regulation Of Blood Coagulation Cellular Metal Ion Homeostasis Blood Coagulation Blood Vessel Morphogenesis Hemostasis Reactive Oxygen Species Metabolic Process Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Wound Healing Vascular Smooth Muscle Contraction Blood Vessel Development Second-messenger-mediated Signaling Cellular Chemical Homeostasis Vasculature Development Ion Homeostasis Inositol Phosphate-mediated Signaling Wound Healing Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Ion Transport Positive Regulation Of Heart Rate Negative Regulation Of Potassium Ion Transport Regulation Of Developmental Pigmentation Positive Regulation Of Ion Transport Positive Regulation Of Catalytic Activity Regulation Of Cellular Component Movement Cellular Homeostasis Response To Wounding Nitric Oxide Metabolic Process Signal Transduction Positive Regulation Of Heart Contraction	G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cyclase Activity Regulation Of Ion Transport Regulation Of Blood Vessel Size Regulation Of Tube Size Muscle Contraction Endothelin Receptor Signaling Pathway Signal Transduction Muscle System Process Vasoconstriction Vasodilation Response To External Stimulus Regulation Of Signaling Blood Circulation Response To Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Smooth Muscle Contraction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Cellular Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Phosphorylation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Apoptotic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Sensory Perception Of Pain Enteric Nervous System Development Response To Ammonium Ion Ion Homeostasis Vascular Smooth Muscle Contraction Renal System Process Response To Stress
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational
Tagcloud (Intersection) ?