DUT and PLEKHF2

Number of citations of the paper that reports this interaction (PubMedID 19060904)
32

Data Source:
BioGRID (two hybrid)

		DUT	PLEKHF2
Description		deoxyuridine triphosphatase	pleckstrin homology and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Extracellular Exosome	Endosome Early Endosome Endoplasmic Reticulum Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Magnesium Ion Binding RNA Binding DUTP Diphosphatase Activity Protein Binding Hydrolase Activity Signaling Receptor Inhibitor Activity Pyrimidine Deoxyribonucleotide Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding	Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Liver Development Nucleobase-containing Compound Metabolic Process DUMP Biosynthetic Process DTMP Biosynthetic Process DNA Replication Nucleotide Metabolic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process Pyrimidine Deoxyribonucleotide Biosynthetic Process Regulation Of Protein-containing Complex Assembly DUTP Catabolic Process	Endosome Organization Endosome To Lysosome Transport Protein Transport
Pathways
Drugs		Deoxyuridine-5'-Diphosphate 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE
Diseases
GWAS		Blood protein levels ( 30072576) Height ( 31562340) Protein quantitative trait loci ( 18464913) Skin pigmentation ( 28300201)	Radiation response ( 20923822)
Interacting Genes		10 interacting genes: BCAS2 CDK1 ESR1 ESRRA ESRRG NUDT18 PLEKHF2 PPARA PPARD SPATA2	168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KCNJ5-AS1 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581
Entrez ID		1854	79666
HPRD ID		03165	15147
Ensembl ID		ENSG00000128951	ENSG00000175895
Uniprot IDs		A0A0C4DGL3 H0YNW5 P33316	Q9H8W4
PDB IDs		1Q5H 1Q5U 2HQU 3ARA 3ARN 3EHW 4MZ5 4MZ6 5H4J 7PWJ 8C8I
Enriched GO Terms of Interacting Partners?		Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Estrogen Response Element Binding Intracellular Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription Steroid Binding Sequence-specific DNA Binding Transcription Coactivator Binding Regulation Of MiRNA Transcription Negative Regulation Of Cholesterol Storage Regulation Of MiRNA Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Fatty Acid Oxidation Regulation Of Inflammatory Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Lipid Storage Regulation Of Fatty Acid Oxidation Intracellular Signal Transduction Response To Wounding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Positive Regulation Of Fatty Acid Metabolic Process Sequence-specific Double-stranded DNA Binding Fibroblast Proliferation Zinc Ion Binding Regulation Of Lipid Storage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Apoptotic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Pronuclear Fusion Positive Regulation Of Transformation Of Host Cell By Virus Linoleic Acid Binding 8-hydroxy-dADP Phosphatase Activity 8-oxo-GDP Phosphatase Activity DGDP Catabolic Process DADP Catabolic Process Regulation Of Heart Growth Regulation Of Developmental Growth Regulation Of Programmed Cell Death Lipid Binding Wound Healing Response To Activity Regulation Of Defense Response	Protein Binding Identical Protein Binding Endoplasmic Reticulum Tubular Network Formation
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