DUT and BCAS2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		DUT	BCAS2
Description		deoxyuridine triphosphatase	BCAS2 pre-mRNA processing factor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Extracellular Exosome	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nucleolus Centrosome Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Magnesium Ion Binding RNA Binding DUTP Diphosphatase Activity Protein Binding Hydrolase Activity Signaling Receptor Inhibitor Activity Pyrimidine Deoxyribonucleotide Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding	Protein Binding
	Biological Process	Liver Development Nucleobase-containing Compound Metabolic Process DUMP Biosynthetic Process DTMP Biosynthetic Process DNA Replication Nucleotide Metabolic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process Pyrimidine Deoxyribonucleotide Biosynthetic Process Regulation Of Protein-containing Complex Assembly DUTP Catabolic Process	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Ovarian Follicle Development MRNA Processing RNA Splicing Protein Catabolic Process Oogenesis Oocyte Development Spindle Assembly
Pathways			mRNA Splicing - Major Pathway
Drugs		Deoxyuridine-5'-Diphosphate 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE
Diseases
GWAS		Blood protein levels ( 30072576) Height ( 31562340) Protein quantitative trait loci ( 18464913) Skin pigmentation ( 28300201)	Autism ( 24189344) Chronotype ( 30696823)
Interacting Genes		10 interacting genes: BCAS2 CDK1 ESR1 ESRRA ESRRG NUDT18 PLEKHF2 PPARA PPARD SPATA2	82 interacting genes: ACY1 AIMP2 ANKHD1 BLK CCDC120 CCDC17 CNOT4 CPSF7 DMRTB1 DUT ECM1 EIF4ENIF1 EMILIN3 ENKD1 EP300 ESR1 ESR2 FAM86C1P FHIT GOLGA2 HGS HNRNPLL HSF2BP IFI35 IKZF3 KRT20 KRT27 KRT31 KRT34 KRT35 KRT36 KRT37 KRT75 KRTAP19-6 KRTAP8-1 LARP4 LMO1 LMO2 LMO3 LMO4 MBNL1 MED29 MIIP MYOZ3 NIP7 OIP5 PAX5 PCBD2 PFDN5 PGR PLAGL2 PLEKHF2 POT1 PPARG PRRC2B QKI RBM22 RBPMS RPL5 SAXO4 SF1 SLAIN1 SMARCD1 SNRNP200 SNRPC SNW1 SPMIP5 SPMIP6 TCF4 TCHP TFIP11 TP53BP2 TRAF1 TRNAU1AP TXN2 TXNRD2 UBC USHBP1 WDR83 YPEL3 ZMAT5 ZWINT
Entrez ID		1854	10286
HPRD ID		03165	05777
Ensembl ID		ENSG00000128951	ENSG00000116752
Uniprot IDs		A0A0C4DGL3 H0YNW5 P33316	B2R7W3 O75934
PDB IDs		1Q5H 1Q5U 2HQU 3ARA 3ARN 3EHW 4MZ5 4MZ6 5H4J 7PWJ 8C8I	5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7W59 7W5A 7W5B 8C6J 8CH6 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Estrogen Response Element Binding Intracellular Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription Steroid Binding Sequence-specific DNA Binding Transcription Coactivator Binding Regulation Of MiRNA Transcription Negative Regulation Of Cholesterol Storage Regulation Of MiRNA Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Fatty Acid Oxidation Regulation Of Inflammatory Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Lipid Storage Regulation Of Fatty Acid Oxidation Intracellular Signal Transduction Response To Wounding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Positive Regulation Of Fatty Acid Metabolic Process Sequence-specific Double-stranded DNA Binding Fibroblast Proliferation Zinc Ion Binding Regulation Of Lipid Storage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Apoptotic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Pronuclear Fusion Positive Regulation Of Transformation Of Host Cell By Virus Linoleic Acid Binding 8-hydroxy-dADP Phosphatase Activity 8-oxo-GDP Phosphatase Activity DGDP Catabolic Process DADP Catabolic Process Regulation Of Heart Growth Regulation Of Developmental Growth Regulation Of Programmed Cell Death Lipid Binding Wound Healing Response To Activity Regulation Of Defense Response	Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Nucleic Acid Binding MRNA Metabolic Process MRNA Processing Structural Molecule Activity Spliceosomal Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Estrogen Response Element Binding RNA Binding RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding RNA Processing Catalytic Step 2 Spliceosome Nucleus Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nuclear Receptor Activity Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Nuclear Receptor-mediated Signaling Pathway Epithelial Cell Differentiation Nuclear Steroid Receptor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Morphogenesis Of An Epithelium MRNA Binding DNA-binding Transcription Factor Binding Regulation Of RNA Splicing Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Protein-containing Complex Organization Steroid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cell Differentiation Supramolecular Fiber Organization Hormone-mediated Signaling Pathway Tissue Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization
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