DYNC1I1 and NAGK

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DYNC1I1	NAGK
Description		dynein cytoplasmic 1 intermediate chain 1	N-acetylglucosamine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome	Cytosol Extracellular Exosome
	Molecular Function	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding	Nucleotide Binding Protein Binding ATP Binding N-acylmannosamine Kinase Activity Kinase Activity Transferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity
	Biological Process	Microtubule-based Movement Transport Along Microtubule Vesicle Transport Along Microtubule	Immune System Process N-acetylglucosamine Metabolic Process N-acetylglucosamine Catabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process Canonical NF-kappaB Signal Transduction N-acetylneuraminate Catabolic Process Response To Muramyl Dipeptide P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Carbohydrate Phosphorylation Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Linear Polyubiquitination
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Synthesis of UDP-N-acetyl-glucosamine
Drugs			N-Acetylglucosamine
Diseases
GWAS		Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Immune reponse to smallpox (secreted IL-10) ( 22610502) Knee osteoarthritis ( 27696742) Multisite chronic pain ( 31194737 33830993) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Refractive error ( 32231278)	Blood protein levels ( 30072576) Erythema nodosum in inflammatory bowel disease ( 24487271)
Interacting Genes		35 interacting genes: ACADM ANXA7 BICD1 CADM4 CDKN1A DCTN1 DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 LCOR MCC NAGK NUDT21 PIN1 RAP1GAP RBPMS RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP YTHDF1	36 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DSCR9 DYNC1I1 FNDC3B GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 NUDC PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82
Entrez ID		1780	55577
HPRD ID		04798	08441
Ensembl ID		ENSG00000158560	ENSG00000124357
Uniprot IDs		A4D1I7 O14576 Q8N542	A0A384N6G7 C9JEV6 Q9UJ70
PDB IDs			2CH5 2CH6
Enriched GO Terms of Interacting Partners?		Dynein Intermediate Chain Binding Dynein Complex Cytoplasmic Dynein Complex Microtubule-based Process Microtubule Microtubule Associated Complex Tau Protein Binding Cytoplasmic Stress Granule Microtubule-based Movement Centrosome Regulation Of Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Intracellular Transport Stress Granule Assembly Identical Protein Binding Microtubule Cytoskeleton Organization Positive Regulation Of Protein Localization To Centrosome Cellular Component Assembly Regulation Of Long-term Synaptic Potentiation Cytoplasm Secretory Vesicle Regulation Of DNA Replication Ciliary Tip Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Response To Phorbol 13-acetate 12-myristate Intracellular MRNA Localization Regulation Of Protein Localization To Centrosome Positive Regulation Of Intracellular Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Binding Microtubule Anchoring At Microtubule Organizing Center Microtubule Cytoskeleton Viral Process Mitotic Cell Cycle Phase Transition Dynactin Binding Replicative Senescence Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway MRNA Export From Nucleus Membraneless Organelle Assembly Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cellular Component Organization Negative Regulation Of Phosphate Metabolic Process Cell Cycle Phase Transition Scaffold Protein Binding Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Cytoskeleton Protein Kinase Binding Transport Along Microtubule Organelle Localization	Nucleoplasm Transcription Regulator Complex Negative Regulation Of DNA Biosynthetic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Cytoplasm Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process HMG Box Domain Binding Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process I-SMAD Binding Response To Transforming Growth Factor Beta Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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