DYNC1I1 and DYNLL2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DYNC1I1	DYNLL2
Gene Name		dynein, cytoplasmic 1, intermediate chain 1	dynein, light chain, LC8-type 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome	Nucleus Centrosome Cytosol Microtubule Plasma Membrane Membrane Myosin Complex Dynein Complex Primary Cilium Ciliary Tip
	Molecular Function	Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding	Motor Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule	Transport Apoptotic Process Organelle Organization Microtubule-based Process Synaptic Target Recognition Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		MHC class II antigen presentation Adaptive Immune System	Organelle biogenesis and maintenance MHC class II antigen presentation Programmed Cell Death Activation of BH3-only proteins Assembly of the primary cilium Intraflagellar transport Adaptive Immune System Intrinsic Pathway for Apoptosis Activation of BMF and translocation to mitochondria
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-10) ( 22610502) Obesity-related traits ( 23251661)
Protein-Protein Interactions		31 interactors: ANXA7 BICD1 C2orf44 CADM4 CDKN1A DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 MCC NAGK NUDT21 PIN1 RAP1GAP RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 UBC	20 interactors: BCL2L11 BMF C12orf40 CCDC36 DLGAP1 DNAL4 DYNC1I1 EWSR1 GPHN GPRIN2 HMBOX1 HOMER3 MEOX2 MORN3 MYO5A PAK1 RASGRP3 SECISBP2L THAP10 XIAP
Entrez ID		1780	140735
HPRD ID		04798	06489
Ensembl ID		ENSG00000158560
Uniprot IDs		A4D1I7 B4DME3 F5H050 G5E9K1 O14576 Q8N542 Q8TBF7	Q96FJ2
PDB IDs			2XQQ 3P8M
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Mitotic Cell Cycle Cell Cycle Process Cell Cycle Mitotic Cell Cycle Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Programmed Cell Death Intracellular MRNA Localization Positive Regulation Of Cell Death Regulation Of Organelle Organization Regulation Of Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Stress Granule Assembly Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Mitochondrion Organization Regulation Of Small GTPase Mediated Signal Transduction Microtubule-based Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Protein Tetramerization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Antigen Processing And Presentation Regulation Of Ras GTPase Activity Viral Process Mitotic Nuclear Division Intracellular Transport Of Virus Response To Metal Ion Positive Regulation Of Apoptotic Process Regulation Of Cell Growth Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction DNA Damage Checkpoint Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Programmed Cell Death Ribonucleoprotein Complex Assembly Negative Regulation Of Phosphorylation	Positive Regulation Of Protein Homooligomerization Positive Regulation Of Protein Oligomerization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Synapse Organization Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Death Regulation Of Intracellular Signal Transduction Receptor Clustering Neuromuscular Junction Development Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Glycine Receptor Clustering Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Developmental Pigmentation Positive Regulation Of Cellular Component Biogenesis Apoptotic Signaling Pathway Protein Localization To Membrane Membrane Organization Positive Regulation Of Protein Linear Polyubiquitination Signaling Regulation Of Mitochondrion Organization Cellular Localization Positive Regulation Of Organelle Organization Cell Communication Vesicle Transport Along Actin Filament Establishment Of Synaptic Specificity At Neuromuscular Junction Endoplasmic Reticulum Localization Apoptotic Process Pigmentation Programmed Cell Death Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process By Virus Odontogenesis Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Fibroblast Apoptotic Process Somite Specification Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Thymocyte Apoptotic Process Anoikis Locomotion Involved In Locomotory Behavior Histone H3-T11 Phosphorylation
Tagcloud ?		10q24 17p13 cgh cnvs congenital deletions dlx5 duplications eexons encompassing enhancer enhancers exonic exons families foot fourth hearing hs1642 kb malformation microdeletions shfm shfm1 split syndromic telomeric tp63 unrelated	associates bicd2 bona chains cilia ciliopathies ciliopathy define dynactin dynein dynlrb1 dynlt1 dynlt3 encoded fide ift intraflagellar lc8 lis1 nudcd3 pafah1b1 retrograde roadblock tctex tctex1d2 wdr34 wdr60
Tagcloud (Difference) ?		10q24 17p13 cgh cnvs congenital deletions dlx5 duplications eexons encompassing enhancer enhancers exonic exons families foot fourth hearing hs1642 kb malformation microdeletions shfm shfm1 split syndromic telomeric tp63 unrelated	associates bicd2 bona chains cilia ciliopathies ciliopathy define dynactin dynein dynlrb1 dynlt1 dynlt3 encoded fide ift intraflagellar lc8 lis1 nudcd3 pafah1b1 retrograde roadblock tctex tctex1d2 wdr34 wdr60
Tagcloud (Intersection) ?