NLGN3 and NRXN2

Number of citations of the paper that reports this interaction (PMID 8576240)
94

Data Source:
HPRD (in vitro)

		NLGN3	NRXN2
Gene Name		neuroligin 3	neurexin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Cell Surface Cell Junction Endocytic Vesicle Synapse Excitatory Synapse	Integral Component Of Membrane
	Molecular Function	Receptor Activity Protein Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity	Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Synapse Assembly Learning Metabolic Process Visual Learning Adult Behavior Social Behavior Axon Extension Oligodendrocyte Differentiation Regulation Of Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Terminal Button Organization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity	Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Neuroligin Clustering Postsynaptic Density Protein 95 Clustering
Pathways
Drugs
Diseases
GWAS			Urate levels ( 21768215 23263486)
Protein-Protein Interactions		8 interactors: DLG2 DLG3 DLG4 MEOX2 NRXN1 NRXN2 NRXN3 PRDX2	9 interactors: CASK DDX24 INADL MACF1 MAPK6 MLLT4 NLGN1 NLGN2 NLGN3
Entrez ID		54413	9379
HPRD ID		02275	11859
Ensembl ID		ENSG00000196338	ENSG00000110076
Uniprot IDs		D3DVV1 Q4G160 Q9NZ94	G5E9G7 P58401 Q9P2S2
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Receptor Clustering Synapse Assembly Synaptic Transmission Neuron Cell-cell Adhesion Protein Localization To Membrane Postsynaptic Membrane Organization Learning Cell-cell Signaling Neuroligin Clustering Synapse Organization Gephyrin Clustering Nucleotide Phosphorylation Vocal Learning Regulation Of Grooming Behavior Learning Or Memory Postsynaptic Membrane Assembly Cognition Postsynaptic Density Protein 95 Clustering Membrane Organization Auditory Behavior Neurotransmitter Secretion Axon Guidance Positive Regulation Of Synapse Maturation Single-organism Behavior Regulation Of Neurotransmitter Levels Regulation Of Synapse Maturation Secretion By Cell Neurological System Process Mechanosensory Behavior Axonogenesis Response To Auditory Stimulus Neurotransmitter Transport Adult Behavior Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Nervous System Development Membrane Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Behavior Cellular Localization Chemotaxis Cellular Protein Localization Membrane Biogenesis Secretion Neuron Projection Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity	Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Membrane Biogenesis Postsynaptic Membrane Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Terminal Button Organization Positive Regulation Of Membrane Potential Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Synapse Assembly Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, GABAergic Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Protein Localization To Synapse Synapse Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cell Adhesion Regulation Of Ion Transport Cell-cell Junction Organization Regulation Of Synaptic Transmission, GABAergic Membrane Hyperpolarization Regulation Of Membrane Potential Regulation Of Dendritic Spine Development Regulation Of Synaptic Transmission Positive Regulation Of Cellular Component Biogenesis Membrane Organization Cell-cell Signaling Protein Localization To Membrane Cellular Component Assembly Regulation Of Neuron Projection Development Positive Regulation Of Ion Transmembrane Transport
Tagcloud ?		88mm alcohol chip chromosomes cpg cyp4f13 defect deficit elavl2 epityper fasd hist1h3d igf2r imprinted imprinting islands landscape medip methylation neurofacial neurulation olfaction remarkably retardation sequenom sim1 sox21 tightly tube	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		88mm alcohol chip chromosomes cpg cyp4f13 defect deficit elavl2 epityper fasd hist1h3d igf2r imprinted imprinting islands landscape medip methylation neurofacial neurulation olfaction remarkably retardation sequenom sim1 sox21 tightly tube	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?