NLGN3 and MAN2C1

Number of citations of the paper that reports this interaction (PubMedID 25464930)
0

Data Source:
BioGRID (two hybrid)

		NLGN3	MAN2C1
Description		neuroligin 3	mannosidase alpha class 2C member 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Endocytic Vesicle Synapse Postsynaptic Membrane Excitatory Synapse Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding	Catalytic Activity Alpha-mannosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Metal Ion Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Cell Adhesion Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential	Carbohydrate Metabolic Process Mannose Metabolic Process Oligosaccharide Catabolic Process
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Lysosomal oligosaccharide catabolism
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)
Interacting Genes		65 interacting genes: AKT1 ALPP AP2A2 APC2 ATF4 ATXN1 C1orf122 C1QA CCAR2 CGB3 COBL CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFEMP1 EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 HIVEP1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12P PICK1 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 RBFOX2 SPAG5 SPINT1 SSR4 TDRD7 TLE5 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1	5 interacting genes: BRCA1 EXOSC6 NLGN3 PRRC2A XRN1
Entrez ID		54413	4123
HPRD ID		02275	01109
Ensembl ID		ENSG00000196338	ENSG00000140400
Uniprot IDs		A0A8I5KSB7 A0A8I5QJH8 B7Z3P8 Q4G160 Q9NZ94 X5D2P6 X5D7L6 X5DNV3	A0A140VJN9 Q9NTJ4
PDB IDs		8GS3
Enriched GO Terms of Interacting Partners?		Receptor Clustering Neuroligin Family Protein Binding Kinase Binding Protein Localization To Cell Junction Vocalization Behavior Social Behavior Protein Localization To Synapse Female Pregnancy Protein Localization To Membrane Cell-cell Adhesion Neuron Cell-cell Adhesion Receptor Localization To Synapse Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Cellular Response To Metal Ion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway GDF15-GFRAL Signaling Pathway Somite Specification Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Localization Within Membrane Ionotropic Glutamate Receptor Binding NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Negative Regulation Of Signal Transduction Neuromuscular Junction Postsynapse Response To Metal Ion Negative Regulation Of Apoptotic Signaling Pathway Postsynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Learning Vocal Learning Cell Adhesion Cell-cell Signaling GMP Kinase Activity Postsynaptic Membrane Organization Neurotransmitter Secretion Observational Learning Cellular Localization Learning Or Memory Protein Kinase Inhibitor Activity Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway PERK-mediated Unfolded Protein Response GDP Metabolic Process	Nuclear MRNA Surveillance RRNA Catabolic Process RNA Surveillance Nuclear RNA Surveillance Regulation Of DNA Metabolic Process RNA Binding Cellular Response To Puromycin Cellular Response To Cycloheximide Nuclear-transcribed MRNA Catabolic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex MRNA Catabolic Process Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse BRCA1-B Complex Asymmetric, Glutamatergic, Excitatory Synapse 5'-3' RNA Exonuclease Activity Negative Regulation Of Centrosome Duplication Negative Regulation Of Centriole Replication BRCA1-A Complex XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Positive Regulation Of DNA Metabolic Process BRCA1-C Complex Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Ubiquitin-modified Histone Reader Activity Positive Regulation Of Developmental Process Response To Indole-3-methanol DNA Strand Resection Involved In Replication Fork Processing Response To Alcohol DNA Recombination Negative Regulation Of Gene Expression DNA Repair Complex Random Inactivation Of X Chromosome Neurexin Family Protein Binding Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Respiratory System Process Inhibitory Postsynaptic Potential Neuron Cell-cell Adhesion Positive Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Regulation Of Glutamate Receptor Signaling Pathway Neuron To Neuron Synapse
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