NLGN3 and NRDC

Number of citations of the paper that reports this interaction (PubMedID 25464930)
0

Data Source:
BioGRID (two hybrid)

		NLGN3	NRDC
Description		neuroligin 3	nardilysin convertase
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Endocytic Vesicle Synapse Postsynaptic Membrane Excitatory Synapse Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse	Mitochondrion Mitochondrial Matrix Cytosol Cell Surface Dendrite Cell Projection
	Molecular Function	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding Epidermal Growth Factor Binding Endopeptidase Activator Activity
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Cell Adhesion Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential	Proteolysis Positive Regulation Of Myelination Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Axonogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)	Appendicular lean mass ( 33097823)
Interacting Genes		65 interacting genes: AKT1 ALPP AP2A2 APC2 ATF4 ATXN1 C1orf122 C1QA CCAR2 CGB3 COBL CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFEMP1 EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 HIVEP1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12P PICK1 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 RBFOX2 SPAG5 SPINT1 SSR4 TDRD7 TLE5 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1	6 interacting genes: CALCA H3C14 HBEGF NLGN3 PDYN POMC
Entrez ID		54413	4898
HPRD ID		02275	04036
Ensembl ID		ENSG00000196338	ENSG00000078618
Uniprot IDs		A0A8I5KSB7 A0A8I5QJH8 B7Z3P8 Q4G160 Q9NZ94 X5D2P6 X5D7L6 X5DNV3	G3V1R5 O43847 Q6UUU9
PDB IDs		8GS3
Enriched GO Terms of Interacting Partners?		Receptor Clustering Neuroligin Family Protein Binding Kinase Binding Protein Localization To Cell Junction Vocalization Behavior Social Behavior Protein Localization To Synapse Female Pregnancy Protein Localization To Membrane Cell-cell Adhesion Neuron Cell-cell Adhesion Receptor Localization To Synapse Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Cellular Response To Metal Ion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway GDF15-GFRAL Signaling Pathway Somite Specification Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Localization Within Membrane Ionotropic Glutamate Receptor Binding NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Negative Regulation Of Signal Transduction Neuromuscular Junction Postsynapse Response To Metal Ion Negative Regulation Of Apoptotic Signaling Pathway Postsynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Learning Vocal Learning Cell Adhesion Cell-cell Signaling GMP Kinase Activity Postsynaptic Membrane Organization Neurotransmitter Secretion Observational Learning Cellular Localization Learning Or Memory Protein Kinase Inhibitor Activity Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway PERK-mediated Unfolded Protein Response GDP Metabolic Process	Cell-cell Signaling Cell Communication Signaling Neuronal Dense Core Vesicle Hippocampal Mossy Fiber To CA3 Synapse Regulation Of System Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Oxytocin Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Amylin Receptor 1 Signaling Pathway Calcitonin Receptor Binding Signaling Receptor Binding Endocytosis Amylin Receptor 2 Signaling Pathway Hormone Activity Insulin Receptor Complex Neuropeptide Signaling Pathway Opioid Receptor Binding Opioid Peptide Activity Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Neutrophil Mediated Killing Of Fungus Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Type 3 Melanocortin Receptor Binding Response To Melanocyte-stimulating Hormone Asymmetric, Glutamatergic, Excitatory Synapse Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse
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