GRIN2C and DLGAP1

Number of citations of the paper that reports this interaction (PubMedID 9694864)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GRIN2C	DLGAP1
Description		glutamate ionotropic receptor NMDA type subunit 2C	DLG associated protein 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane NMDA Selective Glutamate Receptor Complex Organelle Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Postsynaptic Density Membrane Synapse Glutamatergic Synapse Postsynaptic Specialization
	Molecular Function	NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Brain Development Response To Wounding Directional Locomotion Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Excitatory Postsynaptic Potential	Chemical Synaptic Transmission Signaling Modulation Of Chemical Synaptic Transmission
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Femur bone mineral density x serum urate levels interaction ( 34046847)	Alanine aminotransferase levels ( 31219225) Body fat mass ( 28552196) Cardiac Troponin-T levels ( 23247143) Eating disorders ( 22911880) Economic and political preferences (time) ( 22566634) Erythrocyte cadmium concentration in never smokers ( 27005419) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) Initial alcohol sensitivity ( 30276832) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 27182965 25231870) Midgestational circulating levels of PBDEs ( 28235828) Mild age-related type 2 diabetes ( 34737425) Obesity-related traits ( 23251661) Plasma free amino acid levels ( 30659259) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Trunk fat mass ( 28552196) Upper eyelid sagging severity ( 24869959)
Interacting Genes		6 interacting genes: DLG3 DLG4 DLGAP1 ERBIN IL16 PATJ	24 interacting genes: APC DLG1 DLG2 DLG3 DLG4 DLGAP2 DLGAP3 DYNLL1 DYNLL2 FHL2 GRB2 GRIN2A GRIN2C ITSN1 ITSN2 KCNA4 MAGEA11 MAGI2 MYO5A SHANK1 SHANK2 SHANK3 SORBS2 TANC1
Entrez ID		2905	9229
HPRD ID		00699	09260
Ensembl ID		ENSG00000161509	ENSG00000170579
Uniprot IDs		A0A8D9PH81 H0Y2V8 O15398 Q14957 Q8IW23	A0A0A0MTP4 A0A9L9PY43 A8MXQ8 B7Z2J5 O14490 Q6IS01
PDB IDs		8E92 8E93 8E94 8E97 8E98 8E99	5YPO 6TNQ 6TQ0
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Postsynaptic Specialization Glutamatergic Synapse Cell Junction AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Binding Chemical Synaptic Transmission Receptor Clustering Receptor Localization To Synapse Trans-synaptic Signaling Synaptic Signaling Protein Localization To Synapse Protein Localization To Cell Junction Plasma Membrane P2Y1 Nucleotide Receptor Binding Postsynaptic Density Membrane Kinase Binding Basal Protein Localization Bicellular Tight Junction Cell-cell Signaling Signaling Cell Communication Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Positive Regulation Of Neutrophil Activation ErbB-2 Class Receptor Binding Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Adherens Junction AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding NMDA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Monocyte Chemotactic Protein-1 Production Cell Adhesion D1 Dopamine Receptor Binding Positive Regulation Of Interleukin-1 Alpha Production Cerebellar Mossy Fiber Synaptic Vesicle Maturation Neuron Spine Positive Regulation Of Neuron Projection Arborization Postsynapse Hemidesmosome Basolateral Plasma Membrane Postsynaptic Density CD4 Receptor Binding Regulation Of Neutrophil Activation Juxtaparanode Region Of Axon	Postsynaptic Density Ionotropic Glutamate Receptor Binding Neuron Projection Protein Localization To Synapse Synapse Protein Localization To Cell Junction Receptor Clustering Glutamatergic Synapse Protein Localization To Membrane Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Postsynaptic Density Membrane Modulation Of Excitatory Postsynaptic Potential Plasma Membrane Synaptic Receptor Adaptor Activity Vocalization Behavior Localization Within Membrane Scaffold Protein Binding Learning Neuromuscular Junction Ionotropic Glutamate Receptor Signaling Pathway Protein Localization To Postsynaptic Membrane Dendritic Spine Organization Protein Localization To Postsynapse Chemical Synaptic Transmission Associative Learning Cellular Localization Modulation Of Chemical Synaptic Transmission Trans-synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Synaptic Signaling Neuron Projection Organization Postsynapse Organization Neuromuscular Process Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Process Controlling Balance Regulation Of Nervous System Process Postsynaptic Membrane Glutamate Receptor Signaling Pathway Establishment Or Maintenance Of Apical/basal Cell Polarity Social Behavior Regulation Of Neuronal Synaptic Plasticity Signaling Positive Regulation Of Synaptic Transmission Regulation Of Membrane Potential Learning Or Memory Clathrin-dependent Synaptic Vesicle Endocytosis Dendritic Spine Morphogenesis Postsynaptic Density Organization
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