GRIN2C and IL16

Number of citations of the paper that reports this interaction (PubMedID 10479680)
61

Data Source:
HPRD (two hybrid)

		GRIN2C	IL16
Description		glutamate ionotropic receptor NMDA type subunit 2C	interleukin 16
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane NMDA Selective Glutamate Receptor Complex Organelle Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Nuclear Speck Flemming Body
	Molecular Function	NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Signaling Receptor Binding Cytokine Activity Protein Binding CD4 Receptor Binding
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Brain Development Response To Wounding Directional Locomotion Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Excitatory Postsynaptic Potential	Immune System Process Chemotaxis Immune Response Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Regulation Of Calcium Ion Transport Positive Regulation Of Neutrophil Activation
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Other interleukin signaling
Drugs		Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Femur bone mineral density x serum urate levels interaction ( 34046847)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Brown vs. black hair color ( 30531825) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Height ( 31562340) Inattentive symptoms ( 18821565) Interleukin-16 levels ( 27989323) Lymphocyte count ( 32888494) Primary biliary cholangitis ( 28425483)
Interacting Genes		6 interacting genes: DLG3 DLG4 DLGAP1 ERBIN IL16 PATJ	108 interacting genes: ANXA6 BLZF1 BOLA2 BOLA2B CALCOCO2 CAMK1 CARD10 CASP3 CCDC184 CCDC33 CD4 CDK1 CEP72 CSNK2A1 CSNK2A2 CYSRT1 DMRTB1 DUSP7 EFEMP2 FAM124A FHL2 FHL5 FTO GABPB1 GOLGA2 GOLGA6L9 GRIN2A GRIN2B GRIN2C GRIN2D HDAC3 HOMEZ HOOK2 HSF2BP JAKMIP1 KANK2 KCNA3 KCND1 KCND2 KCNJ10 KCNJ15 KCNJ2 KCNJ4 KCTD9 KDM1A KIF16B KIFC3 KRT31 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP3-1 L3MBTL3 LGALS14 LMO3 LNX1 LNX2 MBD3L1 MID2 MIER2 MTUS2 MYOG NOXA1 NTAQ1 OIP5 PDLIM7 PFDN5 PICK1 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PRDM6 PRR13 PSTPIP1 RAPGEF2 RBCK1 RNF144B SERTAD3 SMARCB1 SOHLH1 SPRED1 SUV39H1 TEPSIN TFIP11 TRIB3 TRIM23 TRIM27 TRIM42 TRIP6 UBXN11 USHBP1 WWTR1 ZBTB39 ZIM2 ZNF143 ZNF165 ZNF474 ZNF526 ZNF572 ZNF581 ZNF620 ZNF774 ZNF777 ZNF835 ZNRD2 ZRANB1
Entrez ID		2905	3603
HPRD ID		00699	04329
Ensembl ID		ENSG00000161509	ENSG00000172349
Uniprot IDs		A0A8D9PH81 H0Y2V8 O15398 Q14957 Q8IW23	A0A8C8KBU6 Q14005 Q9UME6
PDB IDs		8E92 8E93 8E94 8E97 8E98 8E99	1I16 1X6D 5FB8
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Postsynaptic Specialization Glutamatergic Synapse Cell Junction AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Binding Chemical Synaptic Transmission Receptor Clustering Receptor Localization To Synapse Trans-synaptic Signaling Synaptic Signaling Protein Localization To Synapse Protein Localization To Cell Junction Plasma Membrane P2Y1 Nucleotide Receptor Binding Postsynaptic Density Membrane Kinase Binding Basal Protein Localization Bicellular Tight Junction Cell-cell Signaling Signaling Cell Communication Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Positive Regulation Of Neutrophil Activation ErbB-2 Class Receptor Binding Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Adherens Junction AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding NMDA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Monocyte Chemotactic Protein-1 Production Cell Adhesion D1 Dopamine Receptor Binding Positive Regulation Of Interleukin-1 Alpha Production Cerebellar Mossy Fiber Synaptic Vesicle Maturation Neuron Spine Positive Regulation Of Neuron Projection Arborization Postsynapse Hemidesmosome Basolateral Plasma Membrane Postsynaptic Density CD4 Receptor Binding Regulation Of Neutrophil Activation Juxtaparanode Region Of Axon	Protein Binding Myosin Phosphatase Regulator Activity NMDA Glutamate Receptor Activity NMDA Selective Glutamate Receptor Complex Excitatory Chemical Synaptic Transmission Ligand-gated Monoatomic Ion Channel Activity Zinc Ion Binding Identical Protein Binding Phosphatase Regulator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Inward Rectifier Potassium Channel Activity Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Channel Complex Glutamate-gated Calcium Ion Channel Activity Keratin Filament Regulation Of RNA Metabolic Process Regulation Of Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Protein Kinase CK2 Complex Directional Locomotion Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Membrane Potassium Ion Transport Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ligand-gated Ion Channel Signaling Pathway Potassium Channel Activity Voltage-gated Potassium Channel Complex Synaptic Transmission, Glutamatergic Potassium Ion Import Across Plasma Membrane PDZ Domain Binding Regulation Of Primary Metabolic Process Protein Complex Oligomerization Stress Fiber A-type (transient Outward) Potassium Channel Activity Metal Ion Binding Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Transcription Corepressor Activity Metal Ion Transport Muscle Cell Development Long-term Synaptic Potentiation Regulation Of Postsynaptic Membrane Potential
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?