ZBTB49 and VAC14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZBTB49	VAC14
Description		zinc finger and BTB domain containing 49	VAC14 component of PIKFYVE complex
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Cytoskeleton	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle	Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways			Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444)	Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)
Interacting Genes		12 interacting genes: CEP70 CIB1 EP300 GOPC PICK1 POT1 TP53 TRAF2 TRAF3 VAC14 ZBTB2 ZBTB8A	107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34
Entrez ID		166793	55697
HPRD ID		10335	07660
Ensembl ID		ENSG00000168826	ENSG00000103043
Uniprot IDs		Q6ZSB9	Q08AM6
PDB IDs			7K1Y
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-binding Transcription Factor Activity Transcription Coactivator Binding Identical Protein Binding Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding CD40 Receptor Complex Regulation Of Cellular Component Organization TORC2 Signaling Positive Regulation Of DNA-binding Transcription Factor Activity Apoptotic Signaling Pathway Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization Programmed Necrotic Cell Death Negative Regulation Of Telomere Maintenance Via Telomerase Platelet Formation Cytokine-mediated Signaling Pathway Apoptotic Process T Cell Lineage Commitment Intrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Tumor Necrosis Factor Receptor Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Programmed Cell Death Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Death RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Telomere Maintenance Positive Regulation Of Gene Expression, Epigenetic Regulation Of Phosphorus Metabolic Process Somitogenesis Peptidyl-lysine Propionylation Segmentation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Transcription Initiation-coupled Chromatin Remodeling Histone Butyryltransferase Activity Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Histone Crotonyltransferase Activity Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Cellular Response To Glucose Starvation Regulation Of Telomere Maintenance Via Telomere Lengthening TORC2 Complex Disassembly	Protein Binding Intermediate Filament
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