DDX5 and FRS3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		DDX5	FRS3
Description		DEAD-box helicase 5	fibroblast growth factor receptor substrate 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding MRNA 3'-UTR Binding Helicase Activity Protein Binding Calmodulin Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding MH2 Domain Binding Pre-mRNA Binding Ribonucleoprotein Complex Binding SMAD Binding Calcium-dependent Protein Binding Nuclear Androgen Receptor Binding R-SMAD Binding Primary MiRNA Binding Promoter-specific Chromatin Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing MRNA Transcription BMP Signaling Pathway Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Primary MiRNA Processing Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Viral Genome Replication Myoblast Differentiation Regulation Of Osteoblast Differentiation Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway MiRNA Transcription Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of MiRNA Transcription Regulation Of Skeletal Muscle Cell Differentiation	Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		SUMOylation of transcription cofactors mRNA Splicing - Major Pathway Estrogen-dependent gene expression Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome	FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs		Artenimol
Diseases		Prostate cancer
GWAS		Lung function (FVC) ( 30804560) Refractive error ( 32231278)	Menarche (age at onset) ( 25231870)
Interacting Genes		39 interacting genes: AKAP8 CALM1 CEBPA CREBBP DDX17 DUX4 ESR1 FBL FRS3 H19 HNRNPA0 HNRNPH2 HNRNPH3 HNRNPK IL7R KHDRBS1 LINC00624 MAPKAPK2 NCOA1 NCOA2 NCOA3 NDRG1 OGT PIAS1 PIK3CA PIN1 PRKCA PSMA3 RBFOX2 RBM10 RBM4 SLC26A4-AS1 SMAD3 SUMO2 TNNT1 TP53 UBE2I USP7 WBP11	112 interacting genes: ACTMAP ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 CFAP68 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KCNJ5-AS1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SAXO4 SCNM1 SH2B1 SHANK3 SLAIN1 SLC67A1-AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30
Entrez ID		1655	10817
HPRD ID		01615	06373
Ensembl ID		ENSG00000108654	ENSG00000137218
Uniprot IDs		J3KTA4 P17844	A0A140VJJ7 O43559
PDB IDs		3FE2 4A4D	2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Regulation Of RNA Splicing Protein-containing Complex Negative Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Nuclear Receptor-mediated Signaling Pathway Nucleic Acid Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Catabolic Process Estrogen Receptor Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Presynaptic Cytosol Signal Transduction MRNA Processing Postsynaptic Cytosol Regulation Of MRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hormone Response To Lipid Transcription Regulator Complex Chromatin Remodeling Chromatin Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Processing Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Keratin Filament Intermediate Filament Protein Binding Outer Ear Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of Transcription By RNA Polymerase II Regulation Of Ossification Cellular Developmental Process Anatomical Structure Morphogenesis Structural Molecule Activity Intermediate Filament Organization Developmental Process Anatomical Structure Formation Involved In Morphogenesis Response To Growth Factor Neurotrophin Receptor Activity Neurotrophin Binding Negative Regulation Of Chondrocyte Proliferation Myelination Intermediate Filament Cytoskeleton Organization Supramolecular Fiber Organization Intermediate Filament-based Process Cell Differentiation Axon Ensheathment Cellular Response To Growth Factor Stimulus
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