DDX5 and RBM4

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		DDX5	RBM4
Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 5	RNA binding motif protein 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Ribonucleoprotein Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytoplasmic Stress Granule Nuclear Speck
	Molecular Function	Transcription Coactivator Activity RNA Helicase Activity ATP-dependent RNA Helicase Activity Protein Binding Calmodulin Binding ATP Binding Enzyme Binding Estrogen Receptor Binding Pre-mRNA Binding Poly(A) RNA Binding Calcium-dependent Protein Binding Androgen Receptor Binding	Nucleotide Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding MiRNA Binding Poly(A) RNA Binding Pre-mRNA Intronic Binding Pre-mRNA Intronic Pyrimidine-rich Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome In Utero Embryonic Development Transcription, DNA-templated Circadian Rhythm Cell Growth Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Viral Genome Replication Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Androgen Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Skeletal Muscle Cell Differentiation	Regulation Of Alternative MRNA Splicing, Via Spliceosome Cap-independent Translational Initiation IRES-dependent Translational Initiation RNA Processing MRNA Processing RNA Splicing Negative Regulation Of Translation Cell Differentiation Negative Regulation Of Translation In Response To Stress Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Translational Initiation Response To Arsenic-containing Substance Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Circadian Regulation Of Translation
Pathways
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		34 interactors: AKAP8 CALM1 CREBBP DDX17 DHX9 EP300 ESR1 ESR2 FBL HNRNPA0 HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK IL7R KHDRBS1 MAPKAPK2 NCOA1 NCOA2 NCOA3 NDRG1 PIAS1 PIK3CA PIN1 PRKCA PSMA3 RBFOX2 RBM10 RBM4 SMAD3 SP1 TNNT1 TP53 WBP11	29 interactors: AQR CCNA1 CDK2 CXorf56 DDX17 DDX5 DGCR14 DHX9 HNRNPF HNRNPH2 HNRNPH3 HNRNPK HNRNPM HNRNPUL1 LRP2BP PABPC1 PRPF31 PTBP2 RBM10 RBM22 RBM23 RBM42 RBM7 SF1 SF3B4 SMAD5 SNRPC TRIB3 U2AF2
Entrez ID		1655	5936
HPRD ID		01615	03982
Ensembl ID		ENSG00000108654	ENSG00000173933
Uniprot IDs		J3KTA4 P17844	Q9BWF3
PDB IDs		3FE2 4A4D	2DNQ
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process RNA Processing Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Rhythmic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Splicing MRNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Signal Transduction Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Gene Expression Signaling Response To Organic Substance Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Cell Communication Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Immune System Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Chromatin Organization Histone Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Response To Stimulus Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Vagina Development Histone Modification Transcription, DNA-templated	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Processing MRNA Metabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Processing Cellular Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of RNA Splicing Regulation Of Nitrogen Compound Metabolic Process MRNA Splice Site Selection Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Ribonucleoprotein Complex Assembly Spliceosomal Complex Assembly Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway MRNA Cis Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Ribonucleoprotein Complex Biogenesis MRNA Stabilization Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Spliceosomal SnRNP Assembly Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Meiotic Cell Cycle Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression
Tagcloud ?		cct5 cd68 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars	ago2 altogether argonaute2 associates c2c12 cap colocalizes cytoplasm deposited entry granules micro micrornas microtubule mrnas myoblast notably participates potentiates recruit ribonucleoprotein ribonucleoproteins ribosome rnas suppress suppresses transiently translation translocates
Tagcloud (Difference) ?		cct5 cd68 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars	ago2 altogether argonaute2 associates c2c12 cap colocalizes cytoplasm deposited entry granules micro micrornas microtubule mrnas myoblast notably participates potentiates recruit ribonucleoprotein ribonucleoproteins ribosome rnas suppress suppresses transiently translation translocates
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