DDX5 and HNRNPH2

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		DDX5	HNRNPH2
Description		DEAD-box helicase 5	heterogeneous nuclear ribonucleoprotein H2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytosol Membrane Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding MRNA 3'-UTR Binding Helicase Activity Protein Binding Calmodulin Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding MH2 Domain Binding Pre-mRNA Binding Ribonucleoprotein Complex Binding SMAD Binding Calcium-dependent Protein Binding Nuclear Androgen Receptor Binding R-SMAD Binding Primary MiRNA Binding Promoter-specific Chromatin Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing MRNA Transcription BMP Signaling Pathway Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Primary MiRNA Processing Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Viral Genome Replication Myoblast Differentiation Regulation Of Osteoblast Differentiation Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway MiRNA Transcription Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of MiRNA Transcription Regulation Of Skeletal Muscle Cell Differentiation	Regulation Of RNA Splicing
Pathways		SUMOylation of transcription cofactors mRNA Splicing - Major Pathway Estrogen-dependent gene expression Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs		Artenimol
Diseases		Prostate cancer
GWAS		Lung function (FVC) ( 30804560) Refractive error ( 32231278)
Interacting Genes		39 interacting genes: AKAP8 CALM1 CEBPA CREBBP DDX17 DUX4 ESR1 FBL FRS3 H19 HNRNPA0 HNRNPH2 HNRNPH3 HNRNPK IL7R KHDRBS1 LINC00624 MAPKAPK2 NCOA1 NCOA2 NCOA3 NDRG1 OGT PIAS1 PIK3CA PIN1 PRKCA PSMA3 RBFOX2 RBM10 RBM4 SLC26A4-AS1 SMAD3 SUMO2 TNNT1 TP53 UBE2I USP7 WBP11	97 interacting genes: CCNK DDX5 FXR1 HNRNPA0 HNRNPUL1 HSF2BP ILF3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MSI1 MSI2 OGT PQBP1 PRMT6 PRPF31 PRPF8 QKI RACK1 RAD21 RBFOX2 RBM10 RBM4 SF1 SNRPC SUMO2 TEKT1 TLE5 WDR83 WEE2-AS1
Entrez ID		1655	3188
HPRD ID		01615	03022
Ensembl ID		ENSG00000108654	ENSG00000126945
Uniprot IDs		J3KTA4 P17844	A0A384MDT2 P55795
PDB IDs		3FE2 4A4D	1WEZ 1WG5 6DG1 8SGH
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Regulation Of RNA Splicing Protein-containing Complex Negative Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Nuclear Receptor-mediated Signaling Pathway Nucleic Acid Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Catabolic Process Estrogen Receptor Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Presynaptic Cytosol Signal Transduction MRNA Processing Postsynaptic Cytosol Regulation Of MRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hormone Response To Lipid Transcription Regulator Complex Chromatin Remodeling Chromatin Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Processing Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process MRNA Destabilization Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Negative Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Motility
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