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DDIT3 and TRIB3
Number of citations of the paper that reports this interaction (PubMedID
15775988
)
38
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HPRD
(in vivo)
DDIT3
TRIB3
Description
DNA damage inducible transcript 3
tribbles pseudokinase 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Transcription Regulator Complex
Cytoplasm
Late Endosome
Cytosol
Protein-DNA Complex
CHOP-C/EBP Complex
RNA Polymerase II Transcription Regulator Complex
CHOP-ATF4 Complex
CHOP-ATF3 Complex
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Transcription Corepressor Activity
Protein Binding
CAMP Response Element Binding Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Leucine Zipper Domain Binding
Protein Heterodimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
Transcription Regulator Activator Activity
Transcription Corepressor Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Kinase Activity
Enzyme Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Mitogen-activated Protein Kinase Kinase Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-protein Transferase Regulator Activity
Ubiquitin Ligase Activator Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Maturation
Diaphragm Contraction
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
ER Overload Response
Response To Unfolded Protein
Sensory Perception Of Sound
Response To Wounding
Anterior/posterior Axis Specification
Gene Expression
Regulation Of Autophagy
Wnt Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Type II Interferon Production
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-8 Production
Response To Endoplasmic Reticulum Stress
Response To Platelet-derived Growth Factor
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Response To Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Cell Redox Homeostasis
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Cell Cycle
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Artery Development
Response To Caloric Restriction
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Calcium Ion Import
Establishment Of Protein Localization To Mitochondrion
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Cold-induced Thermogenesis
Integrated Stress Response Signaling
HRI-mediated Signaling
GDF15-GFRAL Signaling Pathway
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Vascular Associated Smooth Muscle Cell Migration
Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Determination Of Dorsal Identity
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Regulation Of Autophagy
Regulation Of D-glucose Transmembrane Transport
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Regulation Of MAP Kinase Activity
Negative Regulation Of MAPK Cascade
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Insulin Receptor Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of cell death genes
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
PIP3 activates AKT signaling
Activation of AKT2
PPARA activates gene expression
Negative regulation of the PI3K/AKT network
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
Myxoid liposarcoma
GWAS
Brain morphology (MOSTest) (
32665545
)
Information processing speed (
21130836
)
Logical memory (delayed recall) (
29274321
)
Logical memory (immediate recall) (
29274321
)
Interacting Genes
68 interacting genes:
AMOTL2
ATF2
ATF3
ATF4
ATPAF2
BACH1
BACH2
BATF
BATF2
BATF3
CDK6
CEBPB
CEBPE
CEBPG
CRACR2A
CREB3
CREB3L1
CREBL2
CSNK2A1
DBP
DGCR2
DNMT3L
DRC12
EMSY
EP300
EPAS1
F2
FOS
FOSL1
FOSL2
GIMAP6
GIPC1
GP1BA
HOXA5
HSD17B14
IKBKG
JDP2
JUN
JUNB
JUND
KPNA2
LMO2
LNX1
MAFF
MAFG
MAPK14
MCMBP
NFE2L2
NFIL3
PCM1
PICALM
POLR1D
RAI1
RPS3
RPS3A
SNAPC5
SPOP
SRA1
SSX3
TEDC1
TNFSF12
TRIB3
TXN2
TXNDC2
VPS37C
ZBTB25
ZC3H14
ZSCAN31
100 interacting genes:
ACACA
AKAP8L
AKT1
AKT2
APOBEC3A
APOBEC3C
APP
ARMC7
ATF4
BAG3
BCL6
BFSP2
BMPR2
C21orf58
C22orf39
CBX8
CHAF1A
CLCNKA
COPS6
CTAG1A
CTAG1B
DDIT3
DPPA3
DTX2
EEF1G
EFEMP2
EPHB6
EXOSC5
FAAP20
FAM161A
FAM90A1
FBXO7
GDF9
GIT1
GLIS3
GPATCH2L
GRB2
HAT1
HDAC4
HLA-B
HNRNPF
HOXB5
HOXC8
IL16
INCA1
INO80B
IRX6
KANK2
KAT5
KLHL38
KRT26
LENG1
LMO2
LMO3
MDFI
MDM2
MISP
MYC
OIP5
OSTF1
PADI4
PARD6B
PCSK5
PITX2
PKNOX2
PML
PPP1R26
PRKAB2
PRMT5
PRR19
PSMA3
RBM4
RBM48
RELA
RIDA
RPGRIP1
RPSA
SAMD11
SAXO1
SAXO4
SCNM1
SETDB1
SHFL
SNRPC
SPAG8
SPG21
SUOX
TCF19
TEKT3
TEKT4
TLE5
TRIM55
TRIM63
TTC23
TWIST1
UBTD2
USP20
UTP23
ZNF417
ZNF587
Entrez ID
1649
57761
HPRD ID
00529
09836
Ensembl ID
ENSG00000175197
ENSG00000101255
Uniprot IDs
P35638
Q53YD1
B4DMM9
J3KR25
Q96RU7
PDB IDs
Enriched GO Terms of Interacting Partners
?
RNA Polymerase II Transcription Regulator Complex
DNA-binding Transcription Factor Activity
Integrated Stress Response Signaling
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Sequence-specific Double-stranded DNA Binding
Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
DNA Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Transcription Factor AP-1 Complex
Nucleoplasm
Cellular Response To Stress
Regulation Of Metabolic Process
Leukocyte Differentiation
DNA-templated Transcription
Nucleus
Myeloid Cell Differentiation
Mononuclear Cell Differentiation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Signaling Cassette
Cell Differentiation
Myeloid Leukocyte Differentiation
Cellular Developmental Process
Negative Regulation Of RNA Metabolic Process
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Transcription Coregulator Binding
Cell Activation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Nucleus
Protein Binding
Negative Regulation Of Gene Expression
DNA-binding Transcription Factor Binding
Identical Protein Binding
Chromatin Remodeling
Chromatin Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleoplasm
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Regulation Of Gene Expression
Axonemal A Tubule Inner Sheath
Negative Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cytoplasm
Innate Immune Response
PERK-mediated Unfolded Protein Response
CHOP-ATF4 Complex
Axonemal Microtubule
DNA Deamination
Chromatin
RNA Metabolic Process
Response To Radiation
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Macromolecule Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Signal Transduction By P53 Class Mediator
Lewy Body Core
Regulation Of Apoptotic Signaling Pathway
Response To Growth Factor
Response To Light Stimulus
Defense Response To Symbiont
Regulation Of Fatty Acid Beta-oxidation
Response To Interleukin-1
Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Intracellular Signal Transduction
Defense Response To Other Organism
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Translational Initiation
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