DDIT3 and HSD17B14

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		DDIT3	HSD17B14
Gene Name		DNA-damage-inducible transcript 3	hydroxysteroid (17-beta) dehydrogenase 14
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Late Endosome Cytosol CHOP-C/EBP Complex	Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	Estradiol 17-beta-dehydrogenase Activity Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	Blood Vessel Maturation Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus ER Overload Response Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Wnt Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Interleukin-8 Production Response To Endoplasmic Reticulum Stress Response To Starvation MRNA Transcription From RNA Polymerase II Promoter Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Cellular Protein Metabolic Process Regulation Of Transcription Involved In Anterior/posterior Axis Specification Cell Redox Homeostasis Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Negative Regulation Of Determination Of Dorsal Identity	Steroid Catabolic Process Oxidation-reduction Process
Pathways		ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		57 interactors: AMOTL2 ATF2 ATF3 ATF4 ATPAF2 BACH1 BACH2 BATF BATF2 BATF3 C11orf30 C14orf80 CCDC153 CDK6 CEBPB CEBPE CEBPG CREB3 CREB3L1 CSNK2A1 DBP DGCR2 EP300 EPAS1 F2 FOS FOSL1 FOSL2 GIPC1 GP1BA HOXA5 HSD17B14 IKBKG JUN JUNB JUND KPNA2 LMO2 MAFF MAFG MAPK14 MCMBP NFIL3 PICALM POLR1D RAI1 RPS3A SNAPC5 SPOP SRA1 SSX3 TNFSF12 TRIB3 VPS37C ZBTB25 ZC3H14 ZSCAN31	15 interactors: CA8 CDKN2D DDIT3 LINC00152 MIR4435-1HG MPG NEK6 NUDT18 PHF1 PSMA1 SNAPC3 SNRPC SREK1IP1 TBC1D22B WDYHV1
Entrez ID		1649	51171
HPRD ID		00529	16801
Ensembl ID		ENSG00000175197	ENSG00000087076
Uniprot IDs		P35638 Q53YD1	Q9BPX1
PDB IDs			1YDE
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Transcription, DNA-templated Gene Expression RNA Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune System Process Cellular Metabolic Process Regulation Of Cellular Process Response To Endoplasmic Reticulum Stress Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Hemopoiesis Response To Stress Immune System Development Developmental Process Response To Other Organism Leukocyte Differentiation Anatomical Structure Development Response To Biotic Stimulus Circadian Rhythm Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Defense Response Toll-like Receptor 5 Signaling Pathway Organ Development Toll-like Receptor 10 Signaling Pathway System Development	Cellular Response To DNA Damage Stimulus Deoxyribose Phosphate Catabolic Process Cellular Response To Stress Deoxyribonucleotide Catabolic Process Purine Nucleotide Catabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Deoxyribonucleotide Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Determination Of Dorsal Identity GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process Nucleotide Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Involved In Anterior/posterior Axis Specification Regulation Of Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Process Depurination Negative Regulation Of Cell Cycle Programmed Cell Death Cell Cycle Process Cell Death Death MRNA 5'-splice Site Recognition Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Regulation Of Cellular Protein Metabolic Process Cell Cycle Arrest Organophosphate Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway DNA Damage Checkpoint Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process G1/S Transition Of Mitotic Cell Cycle DNA Dealkylation Involved In DNA Repair Autophagic Cell Death Base-excision Repair, AP Site Formation Ribonucleoside Diphosphate Catabolic Process Regulation Of Protein Metabolic Process Nucleoside Diphosphate Catabolic Process Cell Cycle Negative Regulation Of Wnt Signaling Pathway Regulation Of Proteolysis SnRNA Transcription ER Overload Response Mitotic Cell Cycle Process Response To Stress
Tagcloud ?		a5 aapoaii advance aggregated amyloid amyloidosis apoa2c apolipoprotein atf4 atf6 atg5 deposition deposits doi eif2ak3 extracellularly fibril fibrils hspa5 intravenously labinvest online p1 protecting publication r1 senile unfolded xbp1s
Tagcloud (Difference) ?		a5 aapoaii advance aggregated amyloid amyloidosis apoa2c apolipoprotein atf4 atf6 atg5 deposition deposits doi eif2ak3 extracellularly fibril fibrils hspa5 intravenously labinvest online p1 protecting publication r1 senile unfolded xbp1s
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