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DDIT3 and BACH1
Number of citations of the paper that reports this interaction (PubMedID
23661758
)
48
Data Source:
BioGRID
(fluorescent resonance energy transfer)
DDIT3
BACH1
Description
DNA damage inducible transcript 3
BTB domain and CNC homolog 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Transcription Regulator Complex
Cytoplasm
Late Endosome
Cytosol
Protein-DNA Complex
CHOP-C/EBP Complex
RNA Polymerase II Transcription Regulator Complex
CHOP-ATF4 Complex
CHOP-ATF3 Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Transcription Corepressor Activity
Protein Binding
CAMP Response Element Binding Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Leucine Zipper Domain Binding
Protein Heterodimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
Transcription Regulator Activator Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Heme Binding
Ligand-modulated Transcription Factor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Maturation
Diaphragm Contraction
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
ER Overload Response
Response To Unfolded Protein
Sensory Perception Of Sound
Response To Wounding
Anterior/posterior Axis Specification
Gene Expression
Regulation Of Autophagy
Wnt Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Type II Interferon Production
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-8 Production
Response To Endoplasmic Reticulum Stress
Response To Platelet-derived Growth Factor
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Response To Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Cell Redox Homeostasis
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Cell Cycle
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Artery Development
Response To Caloric Restriction
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Calcium Ion Import
Establishment Of Protein Localization To Mitochondrion
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Cold-induced Thermogenesis
Integrated Stress Response Signaling
HRI-mediated Signaling
GDF15-GFRAL Signaling Pathway
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Vascular Associated Smooth Muscle Cell Migration
Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Determination Of Dorsal Identity
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of cell death genes
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Regulation of HMOX1 expression and activity
Heme signaling
Regulation of BACH1 activity
NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs
Diseases
Myxoid liposarcoma
GWAS
Brain morphology (MOSTest) (
32665545
)
Alanine aminotransferase levels (
33547301
)
Aspartate aminotransferase levels (
33547301
)
Creatine kinase levels (
29403010
)
Haemorrhoidal disease (
33888516
)
Pancreatic cancer (
22158540
)
Selective IgA deficiency (
27723758
)
Visceral fat (
22589738
)
Interacting Genes
68 interacting genes:
AMOTL2
ATF2
ATF3
ATF4
ATPAF2
BACH1
BACH2
BATF
BATF2
BATF3
CDK6
CEBPB
CEBPE
CEBPG
CRACR2A
CREB3
CREB3L1
CREBL2
CSNK2A1
DBP
DGCR2
DNMT3L
DRC12
EMSY
EP300
EPAS1
F2
FOS
FOSL1
FOSL2
GIMAP6
GIPC1
GP1BA
HOXA5
HSD17B14
IKBKG
JDP2
JUN
JUNB
JUND
KPNA2
LMO2
LNX1
MAFF
MAFG
MAPK14
MCMBP
NFE2L2
NFIL3
PCM1
PICALM
POLR1D
RAI1
RPS3
RPS3A
SNAPC5
SPOP
SRA1
SSX3
TEDC1
TNFSF12
TRIB3
TXN2
TXNDC2
VPS37C
ZBTB25
ZC3H14
ZSCAN31
18 interacting genes:
ANAPC5
ATF2
BATF2
BRCC3
CFTR
DDIT3
DYNLL1
HMMR
KIF5A
MAFB
MAFK
NR1D1
PATZ1
RBCK1
RPS27A
TCF4
USP7
WAC
Entrez ID
1649
571
HPRD ID
00529
04127
Ensembl ID
ENSG00000175197
ENSG00000156273
Uniprot IDs
P35638
Q53YD1
O14867
PDB IDs
2IHC
8S7D
8UA3
8UA6
8UAH
8UBT
8UBU
8UBV
9GP5
9GR9
9GRA
Enriched GO Terms of Interacting Partners
?
RNA Polymerase II Transcription Regulator Complex
DNA-binding Transcription Factor Activity
Integrated Stress Response Signaling
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Sequence-specific Double-stranded DNA Binding
Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
DNA Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Transcription Factor AP-1 Complex
Nucleoplasm
Cellular Response To Stress
Regulation Of Metabolic Process
Leukocyte Differentiation
DNA-templated Transcription
Nucleus
Myeloid Cell Differentiation
Mononuclear Cell Differentiation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Signaling Cassette
Cell Differentiation
Myeloid Leukocyte Differentiation
Cellular Developmental Process
Negative Regulation Of RNA Metabolic Process
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Transcription Coregulator Binding
Cell Activation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Regulator Complex
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Chromatin
Integrated Stress Response Signaling
Cellular Response To Stress
Regulation Of Nucleobase-containing Compound Metabolic Process
Proteolysis
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of DNA-binding Transcription Factor Activity
CAMP Response Element Binding Protein Binding
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
Leucine Zipper Domain Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of DNA-templated Transcription
Response To Nutrient Levels
DNA Damage Response
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
DNA Damage Checkpoint Signaling
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Post-translational Protein Modification
Nucleus
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Intracellular Signal Transduction
Mononuclear Cell Differentiation
Positive Regulation Of RNA Metabolic Process
Protein Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
T Cell Differentiation
Signal Transduction In Response To DNA Damage
Macromolecule Catabolic Process
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Leukocyte Differentiation
Proteolysis Involved In Protein Catabolic Process
Response To Stress
Regulation Of Insulin Secretion
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellularly ATP-gated Chloride Channel Activity
Positive Regulation Of Voltage-gated Chloride Channel Activity
Sec61 Translocon Complex Binding
Abducens Nucleus Development
Hypoglossal Nucleus Development
DNA Binding
Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
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