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DDIT3 and TNFSF12
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid, two hybrid)
DDIT3
TNFSF12
Description
DNA damage inducible transcript 3
TNF superfamily member 12
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Transcription Regulator Complex
Cytoplasm
Late Endosome
Cytosol
Protein-DNA Complex
CHOP-C/EBP Complex
RNA Polymerase II Transcription Regulator Complex
CHOP-ATF4 Complex
CHOP-ATF3 Complex
Extracellular Region
Extracellular Space
Plasma Membrane
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Transcription Corepressor Activity
Protein Binding
CAMP Response Element Binding Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Leucine Zipper Domain Binding
Protein Heterodimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
Transcription Regulator Activator Activity
Signaling Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Maturation
Diaphragm Contraction
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
ER Overload Response
Response To Unfolded Protein
Sensory Perception Of Sound
Response To Wounding
Anterior/posterior Axis Specification
Gene Expression
Regulation Of Autophagy
Wnt Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Type II Interferon Production
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-8 Production
Response To Endoplasmic Reticulum Stress
Response To Platelet-derived Growth Factor
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Response To Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Cell Redox Homeostasis
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Cell Cycle
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Artery Development
Response To Caloric Restriction
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Calcium Ion Import
Establishment Of Protein Localization To Mitochondrion
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Cold-induced Thermogenesis
Integrated Stress Response Signaling
HRI-mediated Signaling
GDF15-GFRAL Signaling Pathway
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Vascular Associated Smooth Muscle Cell Migration
Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Determination Of Dorsal Identity
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Apoptotic Process
Immune Response
Signal Transduction
Cell Differentiation
Endothelial Cell Migration
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Angiogenesis
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of cell death genes
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
Myxoid liposarcoma
GWAS
Brain morphology (MOSTest) (
32665545
)
Alcohol consumption (drinks per week) (
30643258
)
Apolipoprotein A1 levels (
32203549
)
Atrial fibrillation (
29892015
30061737
)
Brain morphology (MOSTest) (
32665545
)
Chin dimples (
27182965
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Emotional recognition (
31596458
)
HDL cholesterol levels (
32203549
)
Myopia (
27182965
)
Plateletcrit (
32888494
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Triglyceride levels (
32203549
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
68 interacting genes:
AMOTL2
ATF2
ATF3
ATF4
ATPAF2
BACH1
BACH2
BATF
BATF2
BATF3
CDK6
CEBPB
CEBPE
CEBPG
CRACR2A
CREB3
CREB3L1
CREBL2
CSNK2A1
DBP
DGCR2
DNMT3L
DRC12
EMSY
EP300
EPAS1
F2
FOS
FOSL1
FOSL2
GIMAP6
GIPC1
GP1BA
HOXA5
HSD17B14
IKBKG
JDP2
JUN
JUNB
JUND
KPNA2
LMO2
LNX1
MAFF
MAFG
MAPK14
MCMBP
NFE2L2
NFIL3
PCM1
PICALM
POLR1D
RAI1
RPS3
RPS3A
SNAPC5
SPOP
SRA1
SSX3
TEDC1
TNFSF12
TRIB3
TXN2
TXNDC2
VPS37C
ZBTB25
ZC3H14
ZSCAN31
6 interacting genes:
AGGF1
DDIT3
LMNA
SGTA
TNFRSF12A
TNFRSF25
Entrez ID
1649
8742
HPRD ID
00529
04074
Ensembl ID
ENSG00000175197
ENSG00000239697
Uniprot IDs
P35638
Q53YD1
O43508
Q4ACW9
PDB IDs
4HT1
Enriched GO Terms of Interacting Partners
?
RNA Polymerase II Transcription Regulator Complex
DNA-binding Transcription Factor Activity
Integrated Stress Response Signaling
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Sequence-specific Double-stranded DNA Binding
Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
DNA Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Transcription Factor AP-1 Complex
Nucleoplasm
Cellular Response To Stress
Regulation Of Metabolic Process
Leukocyte Differentiation
DNA-templated Transcription
Nucleus
Myeloid Cell Differentiation
Mononuclear Cell Differentiation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Signaling Cassette
Cell Differentiation
Myeloid Leukocyte Differentiation
Cellular Developmental Process
Negative Regulation Of RNA Metabolic Process
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Transcription Coregulator Binding
Cell Activation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Negative Regulation Of Determination Of Dorsal Identity
Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Response To Endoplasmic Reticulum Stress
CHOP-ATF4 Complex
CHOP-ATF3 Complex
Apoptotic Signaling Pathway
Establishment Of Protein Localization To Organelle
DNA Double-strand Break Attachment To Nuclear Envelope
Structural Constituent Of Nuclear Lamina
TRC Complex
Substrate-dependent Cell Migration, Cell Attachment To Substrate
Positive Regulation Of Apoptotic Signaling Pathway
Involuntary Skeletal Muscle Contraction
CHOP-C/EBP Complex
Diaphragm Contraction
Cellular Response To Nitrosative Stress
Identical Protein Binding
Vascular Associated Smooth Muscle Cell Migration
Regulation Of Extrinsic Apoptotic Signaling Pathway
Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
BAT3 Complex Binding
GDF15-GFRAL Signaling Pathway
Lamin Filament
Nuclear Pore Localization
Cell Death
ATF6-mediated Unfolded Protein Response
HRI-mediated Signaling
Apoptotic Process
Response To Endoplasmic Reticulum Stress
Blood Vessel Maturation
Negative Regulation Of Interleukin-4 Production
Response To Nitrosative Stress
Programmed Cell Death
Smooth Muscle Cell Proliferation
Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of ERAD Pathway
Transcription Regulator Activator Activity
PERK-mediated Unfolded Protein Response
ER Overload Response
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
CAMP Response Element Binding Protein Binding
Response To Caloric Restriction
Leucine Zipper Domain Binding
Ventricular Cardiac Muscle Cell Development
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
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Tagcloud (Intersection)
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