DDIT3 and RPS3A

Number of citations of the paper that reports this interaction (PMID 10713066)
8

Data Source:
HPRD (in vivo, in vitro)

		DDIT3	RPS3A
Gene Name		DNA-damage-inducible transcript 3	ribosomal protein S3A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Late Endosome Cytosol CHOP-C/EBP Complex	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding
	Biological Process	Blood Vessel Maturation Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus ER Overload Response Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Wnt Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Interleukin-8 Production Response To Endoplasmic Reticulum Stress Response To Starvation MRNA Transcription From RNA Polymerase II Promoter Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Cellular Protein Metabolic Process Regulation Of Transcription Involved In Anterior/posterior Axis Specification Cell Redox Homeostasis Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Negative Regulation Of Determination Of Dorsal Identity	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cell Differentiation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process
Pathways		ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR)	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			HDL cholesterol ( 20686565)
Protein-Protein Interactions		57 interactors: AMOTL2 ATF2 ATF3 ATF4 ATPAF2 BACH1 BACH2 BATF BATF2 BATF3 C11orf30 C14orf80 CCDC153 CDK6 CEBPB CEBPE CEBPG CREB3 CREB3L1 CSNK2A1 DBP DGCR2 EP300 EPAS1 F2 FOS FOSL1 FOSL2 GIPC1 GP1BA HOXA5 HSD17B14 IKBKG JUN JUNB JUND KPNA2 LMO2 MAFF MAFG MAPK14 MCMBP NFIL3 PICALM POLR1D RAI1 RPS3A SNAPC5 SPOP SRA1 SSX3 TNFSF12 TRIB3 VPS37C ZBTB25 ZC3H14 ZSCAN31	15 interactors: ATF7IP C11orf49 CCDC50 CHN1 DDIT3 EDEM2 FANCC HGS HSP90AA1 NEDD4 PARP1 SAP18 SOD2 TOE1 VDAC2
Entrez ID		1649	6189
HPRD ID		00529	01606
Ensembl ID		ENSG00000175197	ENSG00000145425
Uniprot IDs		P35638 Q53YD1	B7Z3M5 P61247
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Transcription, DNA-templated Gene Expression RNA Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune System Process Cellular Metabolic Process Regulation Of Cellular Process Response To Endoplasmic Reticulum Stress Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Hemopoiesis Response To Stress Immune System Development Developmental Process Response To Other Organism Leukocyte Differentiation Anatomical Structure Development Response To Biotic Stimulus Circadian Rhythm Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Defense Response Toll-like Receptor 5 Signaling Pathway Organ Development Toll-like Receptor 10 Signaling Pathway System Development	Cellular Response To Superoxide Response To Superoxide Response To Oxygen Radical Cellular Response To Reactive Oxygen Species Protein Targeting To Lysosome Reactive Oxygen Species Metabolic Process Protein Localization To Lysosome Removal Of Superoxide Radicals Response To Unfolded Protein Cellular Response To Stress Positive Regulation Of Metabolic Process Protein Targeting To Vacuole Response To Inorganic Substance Establishment Of Protein Localization To Vacuole Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Superoxide Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Lysosomal Transport Regulation Of Signaling Negative Regulation Of Gene Expression Cytoplasmic Transport Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Response To DNA Damage Stimulus Establishment Of Protein Localization To Organelle Vacuolar Transport Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Neuron Development
Tagcloud ?		a5 aapoaii advance aggregated amyloid amyloidosis apoa2c apolipoprotein atf4 atf6 atg5 deposition deposits doi eif2ak3 extracellularly fibril fibrils hspa5 intravenously labinvest online p1 protecting publication r1 senile unfolded xbp1s
Tagcloud (Difference) ?		a5 aapoaii advance aggregated amyloid amyloidosis apoa2c apolipoprotein atf4 atf6 atg5 deposition deposits doi eif2ak3 extracellularly fibril fibrils hspa5 intravenously labinvest online p1 protecting publication r1 senile unfolded xbp1s
Tagcloud (Intersection) ?