IGHM and VPREB3

Number of citations of the paper that reports this interaction (PubMedID 7961773)
0

Data Source:
HPRD (in vivo)

		IGHM	VPREB3
Description		immunoglobulin heavy constant mu	V-set pre-B cell surrogate light chain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Immunoglobulin Complex Extracellular Exosome IgM Immunoglobulin Complex IgM B Cell Receptor Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle	Extracellular Region Endoplasmic Reticulum Immunoglobulin Complex
	Molecular Function	Single-stranded DNA Binding Antigen Binding Protein Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion Immune System Process Defense Response Immune Response Antibacterial Humoral Response Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway	Immune Response
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Systemic sclerosis ( 33069728)	IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391)
Interacting Genes		19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3	2 interacting genes: IGHM VPREB1
Entrez ID		3507	29802
HPRD ID		00912	05426
Ensembl ID		ENSG00000211899	ENSG00000128218
Uniprot IDs			Q9UKI3
PDB IDs
Enriched GO Terms of Interacting Partners?		ER Overload Response Regulation Of Protein Localization To Centrosome Translational Initiation K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Calcium-mediated Signaling Regulation Of Cellular Response To Stress Negative Regulation Of Calcium-mediated Signaling Immunoglobulin Complex Protein Autophosphorylation Molecular Function Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Negative Regulation Of Gene Expression Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Cell Communication Immune System Process Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein ER-nucleus Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Kinase Activity Integrated Stress Response Signaling Regulation Of Protein Folding In Endoplasmic Reticulum Dimeric IgA Immunoglobulin Complex Vascular Endothelial Growth Factor Receptor Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Mitotic DNA Damage Checkpoint Response To Nerve Growth Factor Negative Regulation Of Protein Localization To Nucleus Response To Mechanical Stimulus Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization PTB Domain Binding Presynapse Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury	Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex IgM B Cell Receptor Complex IgM Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Pre-B Cell Allelic Exclusion Positive Regulation Of Glucose Mediated Signaling Pathway Germ Cell Nucleus Regulation Of Glucose Mediated Signaling Pathway Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate BBAF Complex Tat Protein Binding Viral RNA Genome Replication Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I DNA Integration RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Immunoglobulin Receptor Binding XY Body Brahma Complex Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I RSC-type Complex Hepatocyte Differentiation NpBAF Complex NBAF Complex Peptidoglycan Binding Host-mediated Activation Of Viral Transcription Nucleosome Disassembly Viral Genome Replication Protein-DNA Complex Disassembly Phosphatidylcholine Binding Regulation Of Nucleotide-excision Repair Nuclear Chromosome Blastocyst Hatching Blastocyst Development Positive Regulation Of Transcription By RNA Polymerase I SWI/SNF Complex Host-mediated Perturbation Of Viral Transcription Antigen Binding Regulation Of G0 To G1 Transition Host-mediated Activation Of Viral Process Nucleosomal DNA Binding Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Myoblast Differentiation Positive Regulation Of Stem Cell Population Maintenance Transcription Initiation-coupled Chromatin Remodeling B Cell Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Immune System Process
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