IGHM and VPREB1

Number of citations of the paper that reports this interaction (PubMedID 2117639)
9

Data Source:
HPRD (in vitro)

		IGHM	VPREB1
Description		immunoglobulin heavy constant mu	V-set pre-B cell surrogate light chain 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Immunoglobulin Complex Extracellular Exosome IgM Immunoglobulin Complex IgM B Cell Receptor Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle	Extracellular Region Endoplasmic Reticulum Immunoglobulin Complex
	Molecular Function	Single-stranded DNA Binding Antigen Binding Protein Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion Immune System Process Defense Response Immune Response Antibacterial Humoral Response Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway	Immune Response
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Systemic sclerosis ( 33069728)	Diastolic blood pressure ( 29208002) Periodontitis (PAL4Q3) ( 24024966) Response to selective serotonin reuptake inhibitors in depression ( 27622933)
Interacting Genes		19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3	3 interacting genes: IGHM LGALS1 VPREB3
Entrez ID		3507	7441
HPRD ID		00912	05505
Ensembl ID		ENSG00000211899	ENSG00000169575
Uniprot IDs			P12018
PDB IDs			2H32 2H3N 3BJ9
Enriched GO Terms of Interacting Partners?		ER Overload Response Regulation Of Protein Localization To Centrosome Translational Initiation K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Calcium-mediated Signaling Regulation Of Cellular Response To Stress Negative Regulation Of Calcium-mediated Signaling Immunoglobulin Complex Protein Autophosphorylation Molecular Function Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Negative Regulation Of Gene Expression Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Cell Communication Immune System Process Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein ER-nucleus Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Kinase Activity Integrated Stress Response Signaling Regulation Of Protein Folding In Endoplasmic Reticulum Dimeric IgA Immunoglobulin Complex Vascular Endothelial Growth Factor Receptor Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Mitotic DNA Damage Checkpoint Response To Nerve Growth Factor Negative Regulation Of Protein Localization To Nucleus Response To Mechanical Stimulus Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization PTB Domain Binding Presynapse Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury	Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Lactose Binding Galectin Complex IgM B Cell Receptor Complex IgM Immunoglobulin Complex Pre-B Cell Allelic Exclusion Positive Regulation Of Dendritic Cell Differentiation Plasma Cell Differentiation Immune System Process Negative Regulation Of T-helper 17 Cell Lineage Commitment Immunoglobulin Receptor Binding Extracellular Region Negative Regulation Of Cell Fate Commitment Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of Dendritic Cell Differentiation Peptidoglycan Binding Laminin Binding Regulation Of Viral Entry Into Host Cell Negative Regulation Of T-helper Cell Differentiation Positive Regulation Of Viral Life Cycle Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Mature B Cell Differentiation Involved In Immune Response Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Phosphatidylcholine Binding Myoblast Differentiation Mature B Cell Differentiation Antigen Binding Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper 17 Type Immune Response T Cell Costimulation Regulation Of Cell Fate Commitment B Cell Receptor Signaling Pathway Regulation Of Immune Response Negative Regulation Of T Cell Differentiation Regulation Of T-helper Cell Differentiation Negative Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Immune System Process Antibacterial Humoral Response Negative Regulation Of Lymphocyte Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Viral Process B Cell Activation Involved In Immune Response
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