IGHM and MAPKAPK3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		IGHM	MAPKAPK3
Description		immunoglobulin heavy constant mu	MAPK activated protein kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Immunoglobulin Complex Extracellular Exosome IgM Immunoglobulin Complex IgM B Cell Receptor Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Single-stranded DNA Binding Antigen Binding Protein Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion Immune System Process Defense Response Immune Response Antibacterial Humoral Response Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway	MAPK Cascade Toll-like Receptor Signaling Pathway Signal Transduction Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways			p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation
Drugs			2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Systemic sclerosis ( 33069728)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3	21 interacting genes: APP ATF1 BECN1 COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12
Entrez ID		3507	7867
HPRD ID		00912	03678
Ensembl ID		ENSG00000211899	ENSG00000114738
Uniprot IDs			Q16644
PDB IDs			3FHR 3FXW 3R1N 3SHE 7NRB
Enriched GO Terms of Interacting Partners?		ER Overload Response Regulation Of Protein Localization To Centrosome Translational Initiation K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Calcium-mediated Signaling Regulation Of Cellular Response To Stress Negative Regulation Of Calcium-mediated Signaling Immunoglobulin Complex Protein Autophosphorylation Molecular Function Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Negative Regulation Of Gene Expression Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Cell Communication Immune System Process Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein ER-nucleus Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Kinase Activity Integrated Stress Response Signaling Regulation Of Protein Folding In Endoplasmic Reticulum Dimeric IgA Immunoglobulin Complex Vascular Endothelial Growth Factor Receptor Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Mitotic DNA Damage Checkpoint Response To Nerve Growth Factor Negative Regulation Of Protein Localization To Nucleus Response To Mechanical Stimulus Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization PTB Domain Binding Presynapse Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury	Response To Growth Factor Cellular Response To Growth Factor Stimulus Receptor Catabolic Process Response To Hydrogen Peroxide Regulation Of Dendrite Development Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Metabolic Process Regulation Of Synapse Organization Response To Metal Ion Positive Regulation Of Cell Cycle Response To Reactive Oxygen Species Sodium Channel Inhibitor Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Dendrite Morphogenesis Potassium Channel Inhibitor Activity Cellular Response To Hydrogen Peroxide Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Stress Negative Regulation Of Sodium Ion Transport Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Cellular Response To UV MAP Kinase Activity Response To Lead Ion Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Regulation Of Protein Metabolic Process Response To Other Organism Cellular Response To Copper Ion Cellular Response To Light Stimulus Stress-activated MAPK Cascade Cellular Response To Reactive Oxygen Species Cellular Response To Chemical Stress Negative Regulation Of Potassium Ion Transmembrane Transport Intracellular Transport Cytosol Positive Regulation Of Transport Vesicle-mediated Transport Cellular Response To Stress P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Viral Budding Lysosomal Transport Intracellular Signaling Cassette Extracellular Exosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?