IGHM and JCHAIN

Number of citations of the paper that reports this interaction (PubMedID 1472500)
0

Data Source:
HPRD (in vitro)

		IGHM	JCHAIN
Description		immunoglobulin heavy constant mu	joining chain of multimeric IgA and IgM
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Immunoglobulin Complex Extracellular Exosome IgM Immunoglobulin Complex IgM B Cell Receptor Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle	Extracellular Region Extracellular Space Extracellular Exosome Monomeric IgA Immunoglobulin Complex Dimeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Single-stranded DNA Binding Antigen Binding Protein Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding	Single-stranded DNA Binding Antigen Binding IgA Binding Protein-macromolecule Adaptor Activity Phosphatidylcholine Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity Peptidoglycan Binding
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion Immune System Process Defense Response Immune Response Antibacterial Humoral Response Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway	Adaptive Immune Response Glomerular Filtration Immune Response Humoral Immune Response Antibacterial Humoral Response Innate Immune Response Positive Regulation Of Respiratory Burst Protein-containing Complex Assembly
Pathways			Cell surface interactions at the vascular wall Scavenging of heme from plasma
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Systemic sclerosis ( 33069728)
Interacting Genes		19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3	2 interacting genes: CD79A IGHM
Entrez ID		3507	3512
HPRD ID		00912	00991
Ensembl ID		ENSG00000211899	ENSG00000132465
Uniprot IDs			P01591
PDB IDs			6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA 7K0C 7Y09 7Y0H 7Y0J 7YG2 7YSG 7YTC 7YTD 8ADY 8ADZ 8AE0 8AE2 8AE3 8BPE 8BPF 8GZN 8R83 8R84 8SKU 8SKV 8WYR 8WYS 9ARV
Enriched GO Terms of Interacting Partners?		ER Overload Response Regulation Of Protein Localization To Centrosome Translational Initiation K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Calcium-mediated Signaling Regulation Of Cellular Response To Stress Negative Regulation Of Calcium-mediated Signaling Immunoglobulin Complex Protein Autophosphorylation Molecular Function Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Negative Regulation Of Gene Expression Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Cell Communication Immune System Process Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein ER-nucleus Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Kinase Activity Integrated Stress Response Signaling Regulation Of Protein Folding In Endoplasmic Reticulum Dimeric IgA Immunoglobulin Complex Vascular Endothelial Growth Factor Receptor Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Mitotic DNA Damage Checkpoint Response To Nerve Growth Factor Negative Regulation Of Protein Localization To Nucleus Response To Mechanical Stimulus Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization PTB Domain Binding Presynapse Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury	IgM B Cell Receptor Complex B Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Adaptive Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Hexameric IgM Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Immune Response-activating Signaling Pathway B Cell Receptor Complex IgM Immunoglobulin Complex Pre-B Cell Allelic Exclusion Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune Response Immunoglobulin Receptor Binding Peptidoglycan Binding Immunoglobulin Complex Regulation Of Immune Response Positive Regulation Of Immune System Process Phosphatidylcholine Binding Antigen Binding Immune Response B Cell Proliferation Multivesicular Body Antibacterial Humoral Response Regulation Of Immune System Process Defense Response To Gram-negative Bacterium B Cell Differentiation Cell Surface Receptor Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Immune System Process Single-stranded DNA Binding Blood Microparticle Leukocyte Proliferation Antimicrobial Humoral Response
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