OCLN and SYNE4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		OCLN	SYNE4
Gene Name		occludin	spectrin repeat containing, nuclear envelope family member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Tight Junction Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Endocytic Vesicle Cytoplasmic Vesicle	Integral Component Of Nuclear Outer Membrane LINC Complex
	Molecular Function	Structural Molecule Activity Protein Binding Thiopurine S-methyltransferase Activity Protein Domain Specific Binding
	Biological Process	Protein Complex Assembly Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Methylation Cell-cell Junction Organization S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Tight Junction Assembly	Establishment Of Epithelial Cell Apical/basal Polarity
Pathways		Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CLEC7A SYNE4 TJP2 TNFAIP3	52 interactors: ABT1 ADIPOQ BRICD5 C10orf35 C3orf52 CD47 CEP19 CLDN7 CLDN8 CLEC7A CMTM5 CSGALNACT2 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FATE1 GADD45A GSK3B ITM2B KLC4 KLHL12 KLRG1 KTN1 MALL MARCH2 NAGK OCLN OLFM4 OSTCP1 PAQR5 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250
Entrez ID		100506658	163183
HPRD ID			08776
Ensembl ID		ENSG00000197822	ENSG00000181392
Uniprot IDs		A8K3T2 Q16625	Q8N205
PDB IDs		1WPA 1XAW 3G7C
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of CD40 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Osteoclast Proliferation Tolerance Induction To Lipopolysaccharide Positive Regulation Of Innate Immune Response Carbohydrate Mediated Signaling Regulation Of CD40 Signaling Pathway Regulation Of Vascular Wound Healing Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Chronic Inflammatory Response Regulation Of Innate Immune Response Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway B-1 B Cell Homeostasis Establishment Of Endothelial Intestinal Barrier Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Tolerance Induction Regulation Of Hepatocyte Proliferation Protein K11-linked Deubiquitination Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Establishment Of Monopolar Cell Polarity Regulation Of Chronic Inflammatory Response Inflammatory Response Negative Regulation Of Bone Resorption Negative Regulation Of Interleukin-1 Beta Production Regulation Of Germinal Center Formation Immune Response-regulating Signaling Pathway Negative Regulation Of Bone Remodeling Negative Regulation Of Tissue Remodeling Response To Muramyl Dipeptide Protein K48-linked Deubiquitination Phagocytosis, Recognition Protein K63-linked Deubiquitination Establishment Of Epithelial Cell Polarity Epithelial Cell Differentiation Negative Regulation Of Interleukin-2 Production Regulation Of Lipopolysaccharide-mediated Signaling Pathway Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Protein Localization To Vacuole Defense Response To Protozoan	ER To Golgi Vesicle-mediated Transport Negative Regulation Of Binding Regulation Of Binding Golgi Vesicle Transport Adiponectin-activated Signaling Pathway Vesicle Fusion With Golgi Apparatus Negative Regulation Of Protein Binding Response To External Stimulus Regulation Of Glycogen (starch) Synthase Activity Cellular Response To Mechanical Stimulus Vesicle-mediated Transport Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Intracellular Signal Transduction
Tagcloud ?		accordingly ap4 besides bioinformatic cadherin cd44 cdh1 claudins concomitantly conversely crc displays ectopic emt fn1 helix hundreds imply invasion lgr5 mesenchymal myc presumably repressed snail stemness tfap4 transition vim
Tagcloud (Difference) ?		accordingly ap4 besides bioinformatic cadherin cd44 cdh1 claudins concomitantly conversely crc displays ectopic emt fn1 helix hundreds imply invasion lgr5 mesenchymal myc presumably repressed snail stemness tfap4 transition vim
Tagcloud (Intersection) ?