OCLN and CLEC7A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		OCLN	CLEC7A
Description		occludin	C-type lectin domain containing 7A
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Endocytic Vesicle Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Tight Junction Anchoring Junction	Cytoplasm Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Epithelial Cell Migration Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Microtubule Polymerization Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Positive Regulation Of D-glucose Import Protein-containing Complex Assembly Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Tight Junction Organization Protein Localization To Cell Leading Edge Positive Regulation Of Blood-brain Barrier Permeability	Cell Activation Response To Yeast Detection Of Yeast Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Cell Surface Pattern Recognition Receptor Signaling Pathway Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Population Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation T Cell Activation Defense Response To Protozoan Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Lymphocyte Activation Positive Regulation Of Respiratory Burst Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation Positive Regulation Of T-helper 17 Type Immune Response
Pathways		Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions	CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling
Drugs
Diseases		Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome	Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Hand grip strength (Mahalanobis distance) ( 32235003) Interleukin-18 levels ( 27989323)
Interacting Genes		12 interacting genes: CLEC7A CSNK1A1 CSNK2A1 FATE1 GPX8 OGT PTPN2 SNW1 SYNE4 TNFAIP3 ULK1 USP40	48 interacting genes: ADAM33 AIP ARL13B ASGR2 BNIP3 BNIP3L C14orf180 CALM3 CD53 CD74 CFTR CTXN3 CXCL9 FAM3A FCGR1A FNDC9 GJB1 HSPD1 IFNGR2 IL1RL1 JAGN1 KLRC1 KTN1 MTIF3 NEMP1 NINJ2 NSG2 OCLN OLFM4 OPRM1 PTTG1IP RANBP9 RHOU SAR1A SEC22A SGCB SMIM3 SPINT1 SUSD3 SYNE4 TEX29 TLCD4 TMEM79 TMPRSS2 TMPRSS4 UPK2 VSIR ZFPL1
Entrez ID		100506658	64581
HPRD ID			08396
Ensembl ID		ENSG00000197822	ENSG00000172243
Uniprot IDs		A0A0G2JMZ8 A8K3T2 Q16625	A0A0S2Z5Q1 A0A2Z5YRT6 A0A2Z5YRU4 Q68D78 Q9BXN2
PDB IDs		1WPA 1XAW 3G7C
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Protein Catabolic Process Positive Regulation Of Signaling Negative Regulation Of Protein-containing Complex Assembly Sin3-type Complex Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Macroautophagy Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Cellular Response To Nutrient Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To Nutrient Levels Regulation Of Signaling Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Gluconeogenesis Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Mitophagy Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Detection Of Yeast Detection Of Molecule Of Fungal Origin TORC1 Signaling Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Interleukin-2 Production Positive Regulation Of TORC1 Signaling Autophagy Organelle Assembly Regulation Of Insulin Receptor Signaling Pathway Autophagy Of Mitochondrion	Membrane Plasma Membrane Positive Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Life Cycle Protein Binding Mitochondrial Outer Membrane Permeabilization Mitochondrial Protein Catabolic Process Cytokine Receptor Activity External Side Of Plasma Membrane
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