OCLN and USP40

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		OCLN	USP40
Description		occludin	ubiquitin specific peptidase 40
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Endocytic Vesicle Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Tight Junction Anchoring Junction	Nucleus Cytosol
	Molecular Function	Protein Binding Protein Domain Specific Binding	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Epithelial Cell Migration Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Microtubule Polymerization Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Positive Regulation Of D-glucose Import Protein-containing Complex Assembly Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Tight Junction Organization Protein Localization To Cell Leading Edge Positive Regulation Of Blood-brain Barrier Permeability	Proteolysis Protein Deubiquitination Regulation Of Protein Stability
Pathways		Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
Drugs
Diseases		Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome
GWAS		Hand grip strength (Mahalanobis distance) ( 32235003) Interleukin-18 levels ( 27989323)	Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)
Interacting Genes		12 interacting genes: CLEC7A CSNK1A1 CSNK2A1 FATE1 GPX8 OGT PTPN2 SNW1 SYNE4 TNFAIP3 ULK1 USP40	45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA
Entrez ID		100506658	55230
HPRD ID			07166
Ensembl ID		ENSG00000197822	ENSG00000085982
Uniprot IDs		A0A0G2JMZ8 A8K3T2 Q16625	A0A7I2YQ75 C9JK14 Q9NVE5
PDB IDs		1WPA 1XAW 3G7C
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Protein Catabolic Process Positive Regulation Of Signaling Negative Regulation Of Protein-containing Complex Assembly Sin3-type Complex Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Macroautophagy Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Cellular Response To Nutrient Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To Nutrient Levels Regulation Of Signaling Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Gluconeogenesis Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Mitophagy Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Detection Of Yeast Detection Of Molecule Of Fungal Origin TORC1 Signaling Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Interleukin-2 Production Positive Regulation Of TORC1 Signaling Autophagy Organelle Assembly Regulation Of Insulin Receptor Signaling Pathway Autophagy Of Mitochondrion	Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome
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