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AP1B1 and ATR
Number of citations of the paper that reports this interaction (PubMedID
10608806
)
0
Data Source:
BioGRID
(unspecified method)
AP1B1
ATR
Description
adaptor related protein complex 1 subunit beta 1
ATR checkpoint kinase
Image
GO Annotations
Cellular Component
Golgi Membrane
Lysosomal Membrane
Early Endosome
Golgi Apparatus
Cytosol
Synaptic Vesicle
Endomembrane System
Membrane
Membrane Coat
AP-1 Adaptor Complex
Clathrin Adaptor Complex
Cytoplasmic Vesicle Membrane
Clathrin-coated Vesicle Membrane
Cytoplasmic Vesicle
Trans-Golgi Network Membrane
Chromosome, Telomeric Region
Nucleus
Nuclear Envelope
Nucleoplasm
Chromosome
Golgi Apparatus
PML Body
ATR-ATRIP Complex
Site Of DNA Damage
Molecular Function
Protein Binding
Protein Kinase Binding
Clathrin Binding
Nucleotide Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Histone H2AXS139 Kinase Activity
Protein Serine Kinase Activity
Biological Process
Kidney Development
Intracellular Protein Transport
Determination Of Left/right Symmetry
Heart Development
Protein Transport
Vesicle-mediated Transport
Platelet Dense Granule Organization
Basolateral Protein Secretion
Melanosome Assembly
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
Telomere Maintenance
Nucleobase-containing Compound Metabolic Process
DNA Replication
DNA Repair
Double-strand Break Repair
Chromatin Remodeling
DNA Damage Response
Nuclear Envelope Organization
Negative Regulation Of DNA Replication
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Replication Fork Processing
Positive Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To UV
Interstrand Cross-link Repair
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Mitotic G2/M Transition Checkpoint
Response To Arsenic-containing Substance
Nuclear Membrane Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Gamma Radiation
Regulation Of Cellular Response To Stress
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Cellular Response To Heat
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Protein Localization To Site Of Double-strand Break
Regulation Of Double-strand Break Repair
Pathways
Nef mediated downregulation of MHC class I complex cell surface expression
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Meiotic synapsis
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Drugs
Ceralasertib
Diseases
Alveolar rhabdomyosarcoma
Seckel syndrome
GWAS
Aspartate aminotransferase levels (
33547301
)
Carotid atherosclerosis in HIV infection (
20009918
)
Haemorrhoidal disease (
33888516
)
Heel bone mineral density (
28869591
30598549
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
27863252
32888494
)
Pancreatic cancer (
25086665
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Eosinophil count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
29403010
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
27863252
29403010
32888494
)
Red cell distribution width (
28957414
32888494
)
Reticulocyte count (
27863252
)
Reticulocyte fraction of red cells (
27863252
)
Interacting Genes
45 interacting genes:
-
AGR3
AP1G1
AP1M2
ARF1
ARF5
ARF6
ARRB2
ATF7IP
ATM
ATR
BARD1
BUB1
BUB1B
CEBPA
CLTC
CREBBP
CRYBB1
FARS2
FILNC1
FMNL2
FNDC11
GPANK1
GTF2I
KIF13A
LDLRAP1
MLH1
MSGN1
MTNR1B
MYG1
NECAP1
NTRK2
NUP54
PIP5K1C
PLK2
POM121
PRKDC
PSORS1C2
RNF39
SHBG
SLC2A8
SMAD2
TBC1D22B
TSGA10IP
U2AF1
58 interacting genes:
AATF
ABL1
AP1B1
AP3B1
APBB1
ARHGEF1
ATM
BLM
BRCA1
BRCA2
CDKN2C
CEP164
CHD4
CHEK1
CHEK2
CHUK
CLSPN
CREB1
DCAF1
DCLRE1C
DTL
E2F1
E4F1
EEF1E1
EP300
ETAA1
ETV1
FANCA
FANCD2
FANCI
FLT1
H2AX
KDR
LIG4
MCM2
MCPH1
MRE11
MSH2
NBN
NFE2L2
PA2G4
PARP1
PIK3CA
POLD1
POLN
PPP2R3A
RAD17
RASSF1
RHEB
RPA1
TP53
TREX1
UHRF1
UHRF2
UPF1
USP2-AS1
XPA
XRCC5
Entrez ID
162
545
HPRD ID
02541
08369
Ensembl ID
ENSG00000100280
ENSG00000175054
Uniprot IDs
Q10567
Q13535
PDB IDs
4HMY
4P6Z
6CM9
6CRI
6D83
6D84
6DFF
7R4H
7UX3
8D4C
8D4D
8D4E
8D4F
8D4G
8D9R
8D9S
8D9T
8D9U
8D9V
8D9W
5YZ0
Enriched GO Terms of Interacting Partners
?
Histone H2AXS139 Kinase Activity
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Presynaptic Endocytosis
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Negative Regulation Of Cell Cycle
Regulation Of Cellular Response To Heat
Intracellular Protein Localization
Regulation Of Cell Cycle
Clathrin Adaptor Activity
Negative Regulation Of Cell Cycle Process
Establishment Of Protein Localization
DNA-dependent Protein Kinase Activity
Intracellular Protein Transport
Meiotic Sister Chromatid Cohesion, Centromeric
Regulation Of Cell Cycle Phase Transition
Clathrin-coated Pit
Protein Transport
Basolateral Protein Secretion
Mitotic Spindle Assembly Checkpoint Signaling
Negative Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Mitotic Cell Cycle
Clathrin-coated Vesicle Membrane
Vesicle-mediated Transport In Synapse
MutSalpha Complex Binding
Homologous Recombination
Synaptic Vesicle Endocytosis
Negative Regulation Of Mitotic Nuclear Division
Meiotic Telomere Clustering
Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Telomere Localization
Protein Localization To Chromosome
Somatic Cell DNA Recombination
Trans-Golgi Network Membrane
Endocytosis
Somitogenesis
Meiotic Sister Chromatid Cohesion
Male Meiotic Nuclear Division
Nucleotide Binding
Regulation Of Receptor-mediated Endocytosis
Segmentation
Response To Gamma Radiation
Mitotic G2/M Transition Checkpoint
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleic Acid Metabolic Process
Double-strand Break Repair
Signal Transduction In Response To DNA Damage
DNA Damage Checkpoint Signaling
Chromosome, Telomeric Region
Mitotic DNA Damage Checkpoint Signaling
Nucleobase-containing Compound Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
DNA Recombination
Negative Regulation Of Cell Cycle Phase Transition
Response To Stress
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Macromolecule Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Mitotic Cell Cycle
Nucleoplasm
Recombinational Repair
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Response To Radiation
Damaged DNA Binding
Double-strand Break Repair Via Homologous Recombination
Mitotic G2/M Transition Checkpoint
Cellular Response To Radiation
Chromosome Organization
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Primary Metabolic Process
Response To Gamma Radiation
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle G2/M Phase Transition
Mitotic G2 DNA Damage Checkpoint Signaling
Negative Regulation Of Mitotic Cell Cycle Phase Transition
DNA Binding
Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Telomere Maintenance
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Ionizing Radiation
Positive Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
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