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AP1B1 and NTRK2
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
AP1B1
NTRK2
Description
adaptor related protein complex 1 subunit beta 1
neurotrophic receptor tyrosine kinase 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Lysosomal Membrane
Early Endosome
Golgi Apparatus
Cytosol
Synaptic Vesicle
Endomembrane System
Membrane
Membrane Coat
AP-1 Adaptor Complex
Clathrin Adaptor Complex
Cytoplasmic Vesicle Membrane
Clathrin-coated Vesicle Membrane
Cytoplasmic Vesicle
Trans-Golgi Network Membrane
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Postsynaptic Density
Membrane
Axon
Dendrite
Early Endosome Membrane
Cell Projection
Terminal Bouton
Dendritic Spine
Receptor Complex
Axon Terminus
Synapse
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Protein Kinase Binding
Clathrin Binding
Nucleotide Binding
Protease Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Neurotrophin Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Homodimerization Activity
Neurotrophin Binding
Brain-derived Neurotrophic Factor Binding
Brain-derived Neurotrophic Factor Receptor Activity
Biological Process
Kidney Development
Intracellular Protein Transport
Determination Of Left/right Symmetry
Heart Development
Protein Transport
Vesicle-mediated Transport
Platelet Dense Granule Organization
Basolateral Protein Secretion
Melanosome Assembly
Vasculogenesis
Neuron Migration
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Nervous System Development
Learning
Circadian Rhythm
Feeding Behavior
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Glutamate Secretion
Regulation Of Metabolic Process
Neuronal Action Potential Propagation
Central Nervous System Neuron Development
Cerebral Cortex Development
Myelination In Peripheral Nervous System
Cell Differentiation
Neuron Differentiation
Brain-derived Neurotrophic Factor Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Mechanoreceptor Differentiation
Regulation Of GTPase Activity
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Retinal Rod Cell Development
Protein Autophosphorylation
Oligodendrocyte Differentiation
Peripheral Nervous System Neuron Development
Positive Regulation Of Axonogenesis
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synapse Assembly
Retina Development In Camera-type Eye
Long-term Synaptic Potentiation
Cellular Response To Amino Acid Stimulus
Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Negative Regulation Of Amyloid-beta Formation
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Negative Regulation Of Anoikis
Pathways
Nef mediated downregulation of MHC class I complex cell surface expression
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
PIP3 activates AKT signaling
NGF-independant TRKA activation
Constitutive Signaling by Aberrant PI3K in Cancer
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
BDNF activates NTRK2 (TRKB) signaling
NTF3 activates NTRK2 (TRKB) signaling
NTF4 activates NTRK2 (TRKB) signaling
Activated NTRK2 signals through RAS
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PI3K
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FYN
NTRK2 activates RAC1
NTRK2 activates RAC1
Activated NTRK2 signals through CDK5
Drugs
Amitriptyline
Esketamine
Entrectinib
Fostamatinib
Larotrectinib
Diseases
Neuroblastoma
GWAS
Aspartate aminotransferase levels (
33547301
)
Carotid atherosclerosis in HIV infection (
20009918
)
Haemorrhoidal disease (
33888516
)
Heel bone mineral density (
28869591
30598549
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
27863252
32888494
)
Pancreatic cancer (
25086665
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Birth weight (
24950379
)
Body mass index (
25760438
28892062
)
Body size at age 10 (
32376654
)
Gout (normal type) (
32238385
)
Lifetime anxiety disorder (
31748690
)
Menarche (age at onset) (
25231870
)
Parkinson's disease progression (cognitive) (
33111402
)
Refractive error (
32231278
)
Serum metabolite concentrations in chronic kidney disease (
29545352
)
Type 2 diabetes (
31118516
)
Waist-to-hip circumference ratio (recreational physical activity interaction) (
23192594
)
Interacting Genes
45 interacting genes:
-
AGR3
AP1G1
AP1M2
ARF1
ARF5
ARF6
ARRB2
ATF7IP
ATM
ATR
BARD1
BUB1
BUB1B
CEBPA
CLTC
CREBBP
CRYBB1
FARS2
FILNC1
FMNL2
FNDC11
GPANK1
GTF2I
KIF13A
LDLRAP1
MLH1
MSGN1
MTNR1B
MYG1
NECAP1
NTRK2
NUP54
PIP5K1C
PLK2
POM121
PRKDC
PSORS1C2
RNF39
SHBG
SLC2A8
SMAD2
TBC1D22B
TSGA10IP
U2AF1
35 interacting genes:
AP1B1
BDNF
DOK5
DYNLL1
EGFR
ERBB2
ERBB4
FRS2
FRS3
FYN
GIPC1
KIDINS220
NCK1
NCK2
NDFIP1
NGFR
NMNAT1
NTF3
NTF4
PIK3R1
PLCG1
POLR2G
PTPN1
PTPN11
RASGRF1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TRAF6
UBB
USP8
Entrez ID
162
4915
HPRD ID
02541
02712
Ensembl ID
ENSG00000100280
ENSG00000148053
Uniprot IDs
Q10567
A0A8I5KR47
A0A8I5KUZ1
A0A8I5KZB7
A0A8J8YUT9
Q16620
Q548C2
Q5VWE5
PDB IDs
4HMY
4P6Z
6CM9
6CRI
6D83
6D84
6DFF
7R4H
7UX3
8D4C
8D4D
8D4E
8D4F
8D4G
8D9R
8D9S
8D9T
8D9U
8D9V
8D9W
1HCF
1WWB
2MFQ
4ASZ
4AT3
4AT4
4AT5
5MO9
8OYD
Enriched GO Terms of Interacting Partners
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Histone H2AXS139 Kinase Activity
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Presynaptic Endocytosis
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Negative Regulation Of Cell Cycle
Regulation Of Cellular Response To Heat
Intracellular Protein Localization
Regulation Of Cell Cycle
Clathrin Adaptor Activity
Negative Regulation Of Cell Cycle Process
Establishment Of Protein Localization
DNA-dependent Protein Kinase Activity
Intracellular Protein Transport
Meiotic Sister Chromatid Cohesion, Centromeric
Regulation Of Cell Cycle Phase Transition
Clathrin-coated Pit
Protein Transport
Basolateral Protein Secretion
Mitotic Spindle Assembly Checkpoint Signaling
Negative Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Mitotic Cell Cycle
Clathrin-coated Vesicle Membrane
Vesicle-mediated Transport In Synapse
MutSalpha Complex Binding
Homologous Recombination
Synaptic Vesicle Endocytosis
Negative Regulation Of Mitotic Nuclear Division
Meiotic Telomere Clustering
Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Telomere Localization
Protein Localization To Chromosome
Somatic Cell DNA Recombination
Trans-Golgi Network Membrane
Endocytosis
Somitogenesis
Meiotic Sister Chromatid Cohesion
Male Meiotic Nuclear Division
Nucleotide Binding
Regulation Of Receptor-mediated Endocytosis
Segmentation
Response To Gamma Radiation
Mitotic G2/M Transition Checkpoint
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Cell Communication
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Receptor Tyrosine Kinase Binding
Positive Regulation Of Intracellular Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of MAPK Cascade
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Apoptotic Process
Neurotrophin Signaling Pathway
Regulation Of Programmed Cell Death
Signal Transduction
Regulation Of Signal Transduction
Nerve Growth Factor Signaling Pathway
Neurotrophin TRKA Receptor Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Response To Growth Factor
Regulation Of Protein Localization
Cell Projection Organization
Cellular Response To Epidermal Growth Factor Stimulus
Phosphotyrosine Residue Binding
Intracellular Signal Transduction
Cytosol
Nerve Growth Factor Receptor Binding
Response To Epidermal Growth Factor
Insulin Receptor Binding
Negative Regulation Of Programmed Cell Death
Regulation Of Protein Metabolic Process
Ephrin Receptor Binding
Negative Regulation Of Developmental Process
Signaling Adaptor Activity
Modulation Of Chemical Synaptic Transmission
Regulation Of Cell Population Proliferation
Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Cellular Localization
Neuron Projection Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Negative Regulation Of PERK-mediated Unfolded Protein Response
Cell Projection Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Endosome Membrane
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Tagcloud (Intersection)
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