AP1B1 and GTF2I

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AP1B1	GTF2I
Description		adaptor related protein complex 1 subunit beta 1	general transcription factor IIi
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GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Synaptic Vesicle Endomembrane System Membrane Membrane Coat AP-1 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Clathrin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Kidney Development Intracellular Protein Transport Determination Of Left/right Symmetry Heart Development Protein Transport Vesicle-mediated Transport Platelet Dense Granule Organization Basolateral Protein Secretion Melanosome Assembly	Transcription By RNA Polymerase II Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Carotid atherosclerosis in HIV infection ( 20009918) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Pancreatic cancer ( 25086665) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Atrial fibrillation ( 29892015 30061737) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) Sjögren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 28714469 32771030)
Interacting Genes		45 interacting genes: - AGR3 AP1G1 AP1M2 ARF1 ARF5 ARF6 ARRB2 ATF7IP ATM ATR BARD1 BUB1 BUB1B CEBPA CLTC CREBBP CRYBB1 FARS2 FILNC1 FMNL2 FNDC11 GPANK1 GTF2I KIF13A LDLRAP1 MLH1 MSGN1 MTNR1B MYG1 NECAP1 NTRK2 NUP54 PIP5K1C PLK2 POM121 PRKDC PSORS1C2 RNF39 SHBG SLC2A8 SMAD2 TBC1D22B TSGA10IP U2AF1	48 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CEBPA CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 USP7 YY1 ZBTB17 ZMYM3
Entrez ID		162	2969
HPRD ID		02541	03399
Ensembl ID		ENSG00000100280	ENSG00000263001
Uniprot IDs		Q10567	A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09
PDB IDs		4HMY 4P6Z 6CM9 6CRI 6D83 6D84 6DFF 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9T 8D9U 8D9V 8D9W	2D9B 2DN4 2ED2 2EJE
Enriched GO Terms of Interacting Partners?		Histone H2AXS139 Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Presynaptic Endocytosis Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of Cell Cycle Regulation Of Cellular Response To Heat Intracellular Protein Localization Regulation Of Cell Cycle Clathrin Adaptor Activity Negative Regulation Of Cell Cycle Process Establishment Of Protein Localization DNA-dependent Protein Kinase Activity Intracellular Protein Transport Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Cell Cycle Phase Transition Clathrin-coated Pit Protein Transport Basolateral Protein Secretion Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Cell Cycle Clathrin-coated Vesicle Membrane Vesicle-mediated Transport In Synapse MutSalpha Complex Binding Homologous Recombination Synaptic Vesicle Endocytosis Negative Regulation Of Mitotic Nuclear Division Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Telomere Localization Protein Localization To Chromosome Somatic Cell DNA Recombination Trans-Golgi Network Membrane Endocytosis Somitogenesis Meiotic Sister Chromatid Cohesion Male Meiotic Nuclear Division Nucleotide Binding Regulation Of Receptor-mediated Endocytosis Segmentation Response To Gamma Radiation Mitotic G2/M Transition Checkpoint	Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription DNA-binding Transcription Factor Binding Response To Cytokine Response To Peptide Intracellular Signaling Cassette Nucleoplasm Intracellular Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Interleukin-6-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Response To Lipid Cellular Response To Cytokine Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Cellular Response To Stress Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gene Expression Nucleobase-containing Compound Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Protein Modification Process Negative Regulation Of Biosynthetic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Response To Hormone Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Developmental Process
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