PRKCB and RIPK4

Number of citations of the paper that reports this interaction (PMID 11278382)
7

Data Source:
HPRD (in vitro, two hybrid)

		PRKCB	RIPK4
Gene Name		protein kinase C, beta	receptor-interacting serine-threonine kinase 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Membrane
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Calcium Channel Regulator Activity Protein Binding ATP Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T6 Specific) Histone Binding Androgen Receptor Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Apoptotic Process Mitotic Nuclear Envelope Disassembly Signal Transduction Synaptic Transmission Blood Coagulation Negative Regulation Of Glucose Transport Platelet Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Histone H3-T6 Phosphorylation Intracellular Signal Transduction B Cell Activation Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Carbohydrate Stimulus	Morphogenesis Of An Epithelium Protein Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Signaling by the B Cell Receptor (BCR) Trafficking of GluR2-containing AMPA receptors Signaling by GPCR Mitotic Prophase Nuclear Envelope Breakdown Signaling by Wnt VEGFA-VEGFR2 Pathway M Phase Downstream signaling events of B Cell Receptor (BCR) VEGFR2 mediated cell proliferation Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Disinhibition of SNARE formation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Depolymerisation of the Nuclear Lamina Trafficking of AMPA receptors Cell Cycle, Mitotic beta-catenin independent WNT signaling GPCR downstream signaling Signaling by VEGF Activation of NF-kappaB in B cells WNT5A-dependent internalization of FZD4 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Platelet activation, signaling and aggregation PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses
Drugs		Vitamin E O-Phosphoethanolamine Ellagic Acid
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		83 interactors: ADRBK1 AFAP1 ANXA2 ANXA7 BMPR2 BTK CARD11 CASR CD5 CHAT CHUK CISH CSF2RB CYTH2 DAB2 DVL2 EGFR EIF4E EIF6 EP300 EPB41 GABRB2 GABRG2 GAP43 GCNT1 GJA1 GNA12 GNA13 GNB2L1 GRIN1 GRIN2B GRIN2D GRM5 GSK3A GSK3B H1F0 HABP4 HIST1H1A HIST1H1B HIST1H3A HSPA4 IBTK IFNAR2 IKBKB IKBKG ITGB2 ITGB7 KIT LMNB1 LST1 MAPK6 MARCKS MBP MKI67 NCF1 NRGN NUMB PA2G4 PDLIM5 PDLIM7 PDPK1 PEBP1 PPP1CA PPP2CB PPP2R4 PTPN11 RASGRP3 RB1 RGS2 RIPK4 RRAD SDC2 SPTAN1 STXBP1 SYT6 TERF1 TIAM1 TINF2 TOP2A TRIM41 VTN YWHAG ZMYND8	7 interactors: BIRC2 BIRC3 PRKCB PRKCD RHOA TRAF7 XIAP
Entrez ID		5579	54101
HPRD ID		01499	10419
Ensembl ID		ENSG00000166501	ENSG00000183421
Uniprot IDs		P05771	Q96T11 Q9H4D1
PDB IDs		2I0E
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Signaling Developmental Process Regulation Of Cellular Process Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Anatomical Structure Development Programmed Cell Death Multicellular Organismal Development Signaling Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Death Death Cell Communication Apoptotic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Anatomical Structure Morphogenesis Response To Stimulus Response To External Stimulus Regulation Of Signal Transduction Response To Organic Substance Intracellular Signal Transduction Regulation Of Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Morphogenesis Response To Fibroblast Growth Factor System Development Innate Immune Response Response To Stress Fc Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway Cellular Process Generation Of Neurons Regulation Of Kinase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Intracellular Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signal Transduction Regulation Of Inflammatory Response Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Modification Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Necroptotic Process Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Negative Regulation Of Necrotic Cell Death Positive Regulation Of Protein Ubiquitination Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Immune System Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Necrotic Cell Death Regulation Of Apoptotic Process Positive Regulation Of Immune Response Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Ubiquitination Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Necroptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Negative Regulation Of Catalytic Activity Cellular Protein Modification Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Peptidase Activity Response To Stress
Tagcloud ?		axin2 axonogenesis cntn1 coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 snf1lk sod1 tbl1x
Tagcloud (Difference) ?		axin2 axonogenesis cntn1 coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 snf1lk sod1 tbl1x
Tagcloud (Intersection) ?