PRKCB and ANXA2

Number of citations of the paper that reports this interaction (PMID 8898866)
12

Data Source:
HPRD (in vivo, in vitro)

		PRKCB	ANXA2
Gene Name		protein kinase C, beta	annexin A2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Ruffle Basement Membrane Extracellular Space Nucleus Lysosomal Membrane Endosome Early Endosome Lipid Particle Plasma Membrane Cell Cortex Cell Surface Membrane Extrinsic Component Of Plasma Membrane Midbody Extracellular Matrix Late Endosome Membrane Vesicle Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Protein Complex Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Calcium Channel Regulator Activity Protein Binding ATP Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T6 Specific) Histone Binding Androgen Receptor Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Rab GTPase Binding Phospholipase A2 Inhibitor Activity S100 Protein Binding Poly(A) RNA Binding Calcium-dependent Protein Binding
	Biological Process	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Apoptotic Process Mitotic Nuclear Envelope Disassembly Signal Transduction Synaptic Transmission Blood Coagulation Negative Regulation Of Glucose Transport Platelet Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Histone H3-T6 Phosphorylation Intracellular Signal Transduction B Cell Activation Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Carbohydrate Stimulus	Angiogenesis Membrane Raft Assembly Positive Regulation Of Protein Phosphorylation Membrane Budding Body Fluid Secretion Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Osteoclast Development Fibrinolysis Negative Regulation Of Catalytic Activity Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Binding Protein Heterotetramerization Protein Targeting To Plasma Membrane
Pathways		Signaling by the B Cell Receptor (BCR) Trafficking of GluR2-containing AMPA receptors Signaling by GPCR Mitotic Prophase Nuclear Envelope Breakdown Signaling by Wnt VEGFA-VEGFR2 Pathway M Phase Downstream signaling events of B Cell Receptor (BCR) VEGFR2 mediated cell proliferation Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Disinhibition of SNARE formation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Depolymerisation of the Nuclear Lamina Trafficking of AMPA receptors Cell Cycle, Mitotic beta-catenin independent WNT signaling GPCR downstream signaling Signaling by VEGF Activation of NF-kappaB in B cells WNT5A-dependent internalization of FZD4 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Platelet activation, signaling and aggregation PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses	Dissolution of Fibrin Clot Orphan transporters
Drugs		Vitamin E O-Phosphoethanolamine Ellagic Acid	Tenecteplase
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		83 interactors: ADRBK1 AFAP1 ANXA2 ANXA7 BMPR2 BTK CARD11 CASR CD5 CHAT CHUK CISH CSF2RB CYTH2 DAB2 DVL2 EGFR EIF4E EIF6 EP300 EPB41 GABRB2 GABRG2 GAP43 GCNT1 GJA1 GNA12 GNA13 GNB2L1 GRIN1 GRIN2B GRIN2D GRM5 GSK3A GSK3B H1F0 HABP4 HIST1H1A HIST1H1B HIST1H3A HSPA4 IBTK IFNAR2 IKBKB IKBKG ITGB2 ITGB7 KIT LMNB1 LST1 MAPK6 MARCKS MBP MKI67 NCF1 NRGN NUMB PA2G4 PDLIM5 PDLIM7 PDPK1 PEBP1 PPP1CA PPP2CB PPP2R4 PTPN11 RASGRP3 RB1 RGS2 RIPK4 RRAD SDC2 SPTAN1 STXBP1 SYT6 TERF1 TIAM1 TINF2 TOP2A TRIM41 VTN YWHAG ZMYND8	31 interactors: APOH APP CD99 CDC42 CEACAM1 CTSB DYSF GRB2 HMGA1 LGALS13 LYPLA1 MAP3K4 MYOC PHB PLA1A PLAT PLG POT1 PRKCA PRKCB S100A10 S100A4 S100A6 SOS1 SRC STAT6 TERF1 TERT TP53 TRPV5 YWHAQ
Entrez ID		5579	302
HPRD ID		01499	01061
Ensembl ID		ENSG00000166501	ENSG00000182718
Uniprot IDs		P05771	P07355
PDB IDs		2I0E	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4HRH
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Signaling Developmental Process Regulation Of Cellular Process Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Anatomical Structure Development Programmed Cell Death Multicellular Organismal Development Signaling Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Death Death Cell Communication Apoptotic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Anatomical Structure Morphogenesis Response To Stimulus Response To External Stimulus Regulation Of Signal Transduction Response To Organic Substance Intracellular Signal Transduction Regulation Of Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Morphogenesis Response To Fibroblast Growth Factor System Development Innate Immune Response Response To Stress Fc Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway Cellular Process Generation Of Neurons Regulation Of Kinase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Platelet Activation Positive Regulation Of Cellular Component Biogenesis Leukocyte Migration Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization ERBB Signaling Pathway Cell Activation Regulation Of Signaling Telomere Maintenance Via Telomerase Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Developmental Process Regulation Of Apoptotic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Histone H3-T6 Phosphorylation Cellular Component Assembly Regulation Of Cell Death Epidermal Growth Factor Receptor Signaling Pathway Cell Aging Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity RNA-dependent DNA Replication Regulation Of ERBB Signaling Pathway Age-dependent Telomere Shortening Telomere Formation Via Telomerase Regulation Of Cell-substrate Adhesion Negative Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Adhesion Immune System Process Cell Migration Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Organization
Tagcloud ?		axin2 axonogenesis cntn1 coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification	annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Difference) ?		axin2 axonogenesis cntn1 coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification	annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Intersection) ?