PRKCB and IBTK

Number of citations of the paper that reports this interaction (PubMedID 21482705)
0

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		PRKCB	IBTK
Description		protein kinase C beta	inhibitor of Bruton tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Spectrin Membrane Calyx Of Held Extracellular Exosome Presynaptic Cytosol	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Calcium Channel Regulator Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Histone H3T6 Kinase Activity Histone Binding Metal Ion Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity	Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity
	Biological Process	Adaptive Immune Response Immune System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Calcium Ion Transport Intracellular Calcium Ion Homeostasis Apoptotic Process Mitotic Nuclear Membrane Disassembly Signal Transduction Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of D-glucose Transmembrane Transport Negative Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Intracellular Signal Transduction B Cell Activation Lipoprotein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Transport Protein Kinase C Signaling Cellular Response To Carbohydrate Stimulus Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis	Negative Regulation Of Protein Phosphorylation Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Disinhibition of SNARE formation Activation of NF-kappaB in B cells Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerization of the Nuclear Lamina WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Drugs		Vitamin E Tamoxifen Phosphorylcolamine Staurosporine Dequalinium Enzastaurin Ellagic acid Cholecystokinin Benzoyl peroxide alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Blood protein levels ( 30072576) Bone mineral content ( 31790847) Cadmium levels ( 26025379) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime nap ( 33568662) Gut microbiota relative abundance (Dorea) ( 33208821) Inflammatory bowel disease ( 23128233 28067908) Lymphocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Primary biliary cholangitis ( 28062665) Sleep duration ( 30531941) Systemic lupus erythematosus ( 33272962) Ulcerative colitis ( 28067908)	Central corneal thickness ( 29760442 31798171) Corneal resistance factor ( 32716492) Corneal structure ( 23291589) Coronary artery disease ( 33020668) Intraocular pressure ( 29235454 29617998)
Interacting Genes		88 interacting genes: ACSL4 AFAP1 ANXA2 ANXA7 BLVRA BMPR2 BTK CARD11 CASR CD5 CHAT CHUK CISH CSF2RB CYTH2 DAB2 DVL2 EGFR EIF4E EIF6 EP300 EPB41 FBXO7 GABRB2 GABRG2 GAP43 GCNT1 GJA1 GNA12 GNA13 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A GSK3B H1-0 H1-1 H1-5 H3C1 HABP4 HSPA4 IBTK IFNAR2 IKBKB IKBKG ITGB2 ITGB7 KIT LIG1 LMNB1 LST1 MAPK6 MAPT MARCKS MBP MKI67 NCF1 NRGN NUMB PA2G4 PDLIM5 PDLIM7 PDPK1 PEBP1 PPP1CA PPP2CB PTPA PTPN11 RACK1 RASGRP3 RB1 RGS2 RIPK4 RRAD SDC2 SPTAN1 STXBP1 SYT6 TERF1 TIAM1 TINF2 TOP2A TRIM41 VTN YWHAG ZMYND8	6 interacting genes: BTK LAMTOR3 PDCD4 PPP1CA PRKCB PRKD1
Entrez ID		5579	25998
HPRD ID		01499	12105
Ensembl ID		ENSG00000166501	ENSG00000005700
Uniprot IDs		P05771	B7ZLE0 E7EPI0 Q9P2D0
PDB IDs		2I0E 8SG2
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Intracellular Signaling Cassette Positive Regulation Of Cell Communication Regulation Of Developmental Process Cytoplasm Plasma Membrane Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Regulation Of Biological Quality Developmental Process Regulation Of Postsynaptic Membrane Potential Regulation Of Synaptic Plasticity Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Cell Projection Organization Postsynapse Regulation Of Membrane Potential Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Cytosol Regulation Of Protein Localization Calmodulin Binding Positive Regulation Of Transport Regulation Of Transport Regulation Of System Process Regulation Of Cell Growth Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly Neuronal Cell Body Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Phospholipase Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Regulation Of DNA-binding Transcription Factor Activity IkappaB Kinase Complex Cellular Response To Interleukin-3 NMDA Glutamate Receptor Activity Glutamate Binding	Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Cellular Response To Oxygen-containing Compound Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Cell Death Regulation Of Intracellular Signal Transduction Regulation Of NLRP3 Inflammasome Complex Assembly Protein Kinase C Binding B Cell Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Protein Kinase Activity Positive Regulation Of Type I Hypersensitivity Regulation Of Hormone Levels Positive Regulation Of DNA-binding Transcription Factor Activity Phosphate-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport B Cell Affinity Maturation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Histone H3T6 Kinase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Kinase Activity Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Positive Regulation Of Hormone Secretion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Synoviocyte Proliferation
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