PRKCB and H1-5

Number of citations of the paper that reports this interaction (PubMedID 8663071)
0

Data Source:
BioGRID (enzymatic study)

		PRKCB	H1-5
Description		protein kinase C beta	H1.5 linker histone, cluster member
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Spectrin Membrane Calyx Of Held Extracellular Exosome Presynaptic Cytosol	Chromatin Nucleosome Euchromatin Heterochromatin Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Calcium Channel Regulator Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Histone H3T6 Kinase Activity Histone Binding Metal Ion Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Adaptive Immune Response Immune System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Calcium Ion Transport Intracellular Calcium Ion Homeostasis Apoptotic Process Mitotic Nuclear Membrane Disassembly Signal Transduction Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of D-glucose Transmembrane Transport Negative Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Intracellular Signal Transduction B Cell Activation Lipoprotein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Transport Protein Kinase C Signaling Cellular Response To Carbohydrate Stimulus Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Muscle Organ Development Chromosome Condensation Negative Regulation Of DNA Recombination Protein Stabilization Establishment Of Protein Localization To Chromatin
Pathways		Disinhibition of SNARE formation Activation of NF-kappaB in B cells Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerization of the Nuclear Lamina WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		Vitamin E Tamoxifen Phosphorylcolamine Staurosporine Dequalinium Enzastaurin Ellagic acid Cholecystokinin Benzoyl peroxide alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Blood protein levels ( 30072576) Bone mineral content ( 31790847) Cadmium levels ( 26025379) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime nap ( 33568662) Gut microbiota relative abundance (Dorea) ( 33208821) Inflammatory bowel disease ( 23128233 28067908) Lymphocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Primary biliary cholangitis ( 28062665) Sleep duration ( 30531941) Systemic lupus erythematosus ( 33272962) Ulcerative colitis ( 28067908)
Interacting Genes		88 interacting genes: ACSL4 AFAP1 ANXA2 ANXA7 BLVRA BMPR2 BTK CARD11 CASR CD5 CHAT CHUK CISH CSF2RB CYTH2 DAB2 DVL2 EGFR EIF4E EIF6 EP300 EPB41 FBXO7 GABRB2 GABRG2 GAP43 GCNT1 GJA1 GNA12 GNA13 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A GSK3B H1-0 H1-1 H1-5 H3C1 HABP4 HSPA4 IBTK IFNAR2 IKBKB IKBKG ITGB2 ITGB7 KIT LIG1 LMNB1 LST1 MAPK6 MAPT MARCKS MBP MKI67 NCF1 NRGN NUMB PA2G4 PDLIM5 PDLIM7 PDPK1 PEBP1 PPP1CA PPP2CB PTPA PTPN11 RACK1 RASGRP3 RB1 RGS2 RIPK4 RRAD SDC2 SPTAN1 STXBP1 SYT6 TERF1 TIAM1 TINF2 TOP2A TRIM41 VTN YWHAG ZMYND8	32 interacting genes: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDC42 CDK1 CDK2 CDK5 CDKN1A CDKN1B CEBPA EHMT2 HPF1 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PARP1 PARP2 PRKCA PRKCB PRKCD PRKCZ RIPK3 RPS6KA5 SERPINH1 SIRT1
Entrez ID		5579	3009
HPRD ID		01499	00821
Ensembl ID		ENSG00000166501	ENSG00000184357
Uniprot IDs		P05771	P16401
PDB IDs		2I0E 8SG2	2RHI
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Intracellular Signaling Cassette Positive Regulation Of Cell Communication Regulation Of Developmental Process Cytoplasm Plasma Membrane Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Regulation Of Biological Quality Developmental Process Regulation Of Postsynaptic Membrane Potential Regulation Of Synaptic Plasticity Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Cell Projection Organization Postsynapse Regulation Of Membrane Potential Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Cytosol Regulation Of Protein Localization Calmodulin Binding Positive Regulation Of Transport Regulation Of Transport Regulation Of System Process Regulation Of Cell Growth Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly Neuronal Cell Body Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Phospholipase Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Regulation Of DNA-binding Transcription Factor Activity IkappaB Kinase Complex Cellular Response To Interleukin-3 NMDA Glutamate Receptor Activity Glutamate Binding	Chromatin Remodeling Protein Modification Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Serine Kinase Activity Chromatin Binding Protein Serine/threonine Kinase Activity Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Nucleoplasm Regulation Of DNA Metabolic Process Protein Kinase Activity Regulation Of Cell Cycle Cellular Response To Oxygen-containing Compound Cellular Response To Stress Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Macromolecule Biosynthetic Process Response To Stress Nucleus Protein Kinase Binding Cyclin A2-CDK2 Complex Negative Regulation Of Macromolecule Biosynthetic Process Protein Phosphorylation Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Intracellular Signal Transduction Phosphorylation Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Positive Regulation Of DNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of RNA Metabolic Process Cell Cycle G2/M Phase Transition
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