PRKCB and IKBKB

Number of citations of the paper that reports this interaction (PMID 12070292)
34

Data Source:
HPRD (in vitro)

		PRKCB	IKBKB
Gene Name		protein kinase C, beta	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Calcium Channel Regulator Activity Protein Binding ATP Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T6 Specific) Histone Binding Androgen Receptor Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Apoptotic Process Mitotic Nuclear Envelope Disassembly Signal Transduction Synaptic Transmission Blood Coagulation Negative Regulation Of Glucose Transport Platelet Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Histone H3-T6 Phosphorylation Intracellular Signal Transduction B Cell Activation Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Carbohydrate Stimulus	B Cell Homeostasis Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To Virus Positive Regulation Of Sodium Ion Transport Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Serine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cation Channel Activity
Pathways		Signaling by the B Cell Receptor (BCR) Trafficking of GluR2-containing AMPA receptors Signaling by GPCR Mitotic Prophase Nuclear Envelope Breakdown Signaling by Wnt VEGFA-VEGFR2 Pathway M Phase Downstream signaling events of B Cell Receptor (BCR) VEGFR2 mediated cell proliferation Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Disinhibition of SNARE formation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Depolymerisation of the Nuclear Lamina Trafficking of AMPA receptors Cell Cycle, Mitotic beta-catenin independent WNT signaling GPCR downstream signaling Signaling by VEGF Activation of NF-kappaB in B cells WNT5A-dependent internalization of FZD4 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Platelet activation, signaling and aggregation PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival RIP-mediated NFkB activation via ZBP1 IRAK1 recruits IKK complex Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade TCR signaling Signaling by Interleukins Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex Downstream TCR signaling p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System Signalling by NGF IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA p75 NTR receptor-mediated signalling Cytokine Signaling in Immune system MyD88-independent cascade Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs		Vitamin E O-Phosphoethanolamine Ellagic Acid	Mesalazine Sulfasalazine Auranofin Arsenic trioxide
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		83 interactors: ADRBK1 AFAP1 ANXA2 ANXA7 BMPR2 BTK CARD11 CASR CD5 CHAT CHUK CISH CSF2RB CYTH2 DAB2 DVL2 EGFR EIF4E EIF6 EP300 EPB41 GABRB2 GABRG2 GAP43 GCNT1 GJA1 GNA12 GNA13 GNB2L1 GRIN1 GRIN2B GRIN2D GRM5 GSK3A GSK3B H1F0 HABP4 HIST1H1A HIST1H1B HIST1H3A HSPA4 IBTK IFNAR2 IKBKB IKBKG ITGB2 ITGB7 KIT LMNB1 LST1 MAPK6 MARCKS MBP MKI67 NCF1 NRGN NUMB PA2G4 PDLIM5 PDLIM7 PDPK1 PEBP1 PPP1CA PPP2CB PPP2R4 PTPN11 RASGRP3 RB1 RGS2 RIPK4 RRAD SDC2 SPTAN1 STXBP1 SYT6 TERF1 TIAM1 TINF2 TOP2A TRIM41 VTN YWHAG ZMYND8	78 interactors: ACVR1 AKT1 AURKA BCL10 CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 CSF2RA CSF2RB CTNNB1 CUEDC2 EIF2AK2 EIF2AK3 FAF1 FANCA FOXO3 HSP90AA1 HSP90AB1 HTT IKBKAP IKBKG IRS1 JUN MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR RIPK1 ROCK1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 UBB YWHAB
Entrez ID		5579	3551
HPRD ID		01499	04462
Ensembl ID		ENSG00000166501	ENSG00000104365
Uniprot IDs		P05771	O14920
PDB IDs		2I0E	3BRT 3BRV 4E3C 4KIK
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Signaling Developmental Process Regulation Of Cellular Process Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Anatomical Structure Development Programmed Cell Death Multicellular Organismal Development Signaling Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Death Death Cell Communication Apoptotic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Anatomical Structure Morphogenesis Response To Stimulus Response To External Stimulus Regulation Of Signal Transduction Response To Organic Substance Intracellular Signal Transduction Regulation Of Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Morphogenesis Response To Fibroblast Growth Factor System Development Innate Immune Response Response To Stress Fc Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway Cellular Process Generation Of Neurons Regulation Of Kinase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Regulation Of Immune System Process Immune Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Defense Response Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Metabolic Process Cell Death Innate Immune Response-activating Signal Transduction Toll-like Receptor Signaling Pathway Death Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of Innate Immune Response Regulation Of Innate Immune Response Programmed Cell Death Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Immune System Process Response To Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Response To Organic Substance Positive Regulation Of Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Cell Communication Cellular Response To Organic Substance Regulation Of Cell Death Positive Regulation Of Innate Immune Response Negative Regulation Of Programmed Cell Death Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Phosphorylation
Tagcloud ?		axin2 axonogenesis cntn1 coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification	abi analyse ctla4 episodes genotyped il4ra il8 map3k1 mbl2 nfkbia nfkbib polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing
Tagcloud (Difference) ?		axin2 axonogenesis cntn1 coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification	abi analyse ctla4 episodes genotyped il4ra il8 map3k1 mbl2 nfkbia nfkbib polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing
Tagcloud (Intersection) ?