ZMAT2 and TRIM37

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ZMAT2	TRIM37
Description		zinc finger matrin-type 2	tripartite motif containing 37
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome	Chromosome Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Negative Regulation Of Transcription By RNA Polymerase II Protein Monoubiquitination Protein Import Into Peroxisome Matrix Protein Ubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Protein Stabilization Protein Autoubiquitination Aggresome Assembly
Pathways		mRNA Splicing - Major Pathway	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Major depressive disorder ( 27479909) Refractive error ( 32231278) Schizophrenia ( 28991256 29483656) Serum immune biomarker levels ( 32066700) Systolic blood pressure ( 30224653)	Cognitive function ( 25644384) General cognitive ability ( 29844566) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)
Interacting Genes		41 interacting genes: AK8 AMH BICD2 CALCOCO1 CBY2 CCDC57 CDR2 CEBPA CEP76 ERBB2 FSD2 FXR1 FXR2 GOLGA2 GOLGA6L9 GRIPAP1 HAP1 HMBOX1 IKZF1 KANK2 KRT40 LZTS2 MEOX2 MTUS2 NAB2 NUTF2 PHC2 PICK1 PRPH SPAG5 SSX2IP TFEC TFIP11 TNIP1 TRAF2 TRIM36 TRIM37 TSEN15 VPS52 ZBTB14 ZBTB8A	76 interacting genes: ANKRD11 APEX2 APTX AQP1 ARNT2 AXIN1 BASP1 BYSL CCDC33 CDC20B CDC7 CDK5RAP2 CDKL3 COPB1 CWF19L2 DDX6 DLGAP5 DSCAM DTNB DZIP1L ELOA ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PABPC4 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 SYTL4 TCEANC TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZBTB24 ZMAT2 ZNF329 ZNF417 ZNF587 ZNF655
Entrez ID		153527	4591
HPRD ID		08094	05463
Ensembl ID		ENSG00000146007	ENSG00000108395
Uniprot IDs		Q96NC0	O94972
PDB IDs		5O9Z 6AHD 7AAV 7ABF 7ABG 7ABI 8H6K 8Q7N 8QO9 8QPE 8QZS	3LRQ
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule-based Process Cytoskeleton Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Centrosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Protein Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity MRNA Transport Cytoplasm Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Microtubule-based Process RNA Transport Cellular Localization Microtubule Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Translation Regulator Activity Cytosol	Ubiquitin Conjugating Enzyme Activity Nucleus Thioesterase Binding Protein K48-linked Ubiquitination Signaling Adaptor Activity Protein Polyubiquitination Tumor Necrosis Factor Receptor Binding Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Binding Protein Ubiquitination Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Polynucleotide 3'-phosphatase Activity Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process DNA Damage Response Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Post-translational Protein Modification Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Elongin Complex Tumor Necrosis Factor Receptor Superfamily Complex ISG15 Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Proteasomal Protein Catabolic Process Protein Autoubiquitination
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