ZMAT2 and PRPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZMAT2	PRPH
Description		zinc finger matrin-type 2	peripherin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome	Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Membrane Axon Cell Projection Perikaryon Type III Intermediate Filament Extracellular Exosome
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Intermediate Filament Organization
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Major depressive disorder ( 27479909) Refractive error ( 32231278) Schizophrenia ( 28991256 29483656) Serum immune biomarker levels ( 32066700) Systolic blood pressure ( 30224653)	Prostate cancer ( 21743467) Sural nerve amplitude potential ( 30992453)
Interacting Genes		41 interacting genes: AK8 AMH BICD2 CALCOCO1 CBY2 CCDC57 CDR2 CEBPA CEP76 ERBB2 FSD2 FXR1 FXR2 GOLGA2 GOLGA6L9 GRIPAP1 HAP1 HMBOX1 IKZF1 KANK2 KRT40 LZTS2 MEOX2 MTUS2 NAB2 NUTF2 PHC2 PICK1 PRPH SPAG5 SSX2IP TFEC TFIP11 TNIP1 TRAF2 TRIM36 TRIM37 TSEN15 VPS52 ZBTB14 ZBTB8A	34 interacting genes: CDC37 CT55 DDX6 DES FCHO1 INCA1 KIFC3 KRT14 KRT15 KRT16 KRT20 KRT24 KRT27 KRT31 LCA5L LENG1 LMNB1 LNX1 MAGOHB MYO5A NXF1 PIAS2 PPP1R13B PPP1R18 PRKAA2 PRPH2 PSMA1 TCEA2 TCP10L TTC23 VIM ZC4H2 ZMAT2 ZNF572
Entrez ID		153527	5630
HPRD ID		08094	01365
Ensembl ID		ENSG00000146007	ENSG00000135406
Uniprot IDs		Q96NC0	B3KWQ6 P41219
PDB IDs		5O9Z 6AHD 7AAV 7ABF 7ABG 7ABI 8H6K 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		Regulation Of Microtubule-based Process Cytoskeleton Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Centrosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Protein Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity MRNA Transport Cytoplasm Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Microtubule-based Process RNA Transport Cellular Localization Microtubule Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Translation Regulator Activity Cytosol	Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Structural Constituent Of Skin Epidermis Structural Constituent Of Cytoskeleton Keratin Filament Supramolecular Fiber Organization Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organization Epithelial Cell Differentiation Keratin Filament Binding Cytoskeleton Extracellular Exosome Intermediate Filament Cytoskeleton Epidermis Development Protein Binding Organelle Organization Hair Cycle Scaffold Protein Binding Cytoplasmic Stress Granule Nuclear Envelope Organization
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