TLCD4 and CLEC7A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLCD4	CLEC7A
Description		TLC domain containing 4	C-type lectin domain containing 7A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Cytoplasm Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Lipid Homeostasis	Cell Activation Response To Yeast Detection Of Yeast Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Cell Surface Pattern Recognition Receptor Signaling Pathway Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Population Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation T Cell Activation Defense Response To Protozoan Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Lymphocyte Activation Positive Regulation Of Respiratory Burst Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation Positive Regulation Of T-helper 17 Type Immune Response
Pathways			CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling
Drugs
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS
Interacting Genes		72 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CFTR CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC41A1 SLC67A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4	48 interacting genes: ADAM33 AIP ARL13B ASGR2 BNIP3 BNIP3L C14orf180 CALM3 CD53 CD74 CFTR CTXN3 CXCL9 FAM3A FCGR1A FNDC9 GJB1 HSPD1 IFNGR2 IL1RL1 JAGN1 KLRC1 KTN1 MTIF3 NEMP1 NINJ2 NSG2 OCLN OLFM4 OPRM1 PTTG1IP RANBP9 RHOU SAR1A SEC22A SGCB SMIM3 SPINT1 SUSD3 SYNE4 TEX29 TLCD4 TMEM79 TMPRSS2 TMPRSS4 UPK2 VSIR ZFPL1
Entrez ID		148534	64581
HPRD ID		08110	08396
Ensembl ID		ENSG00000152078	ENSG00000172243
Uniprot IDs		Q96MV1	A0A0S2Z5Q1 A0A2Z5YRT6 A0A2Z5YRU4 Q68D78 Q9BXN2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Steroid Biosynthetic Process Membrane Fusion Serine Import Into Mitochondrion Lipid Metabolic Process Sterol Metabolic Process Cholesterol Transport Establishment Of Protein Localization Sterol Transport Membrane Organization Organic Cation Transport Import Into The Mitochondrion Protein Transport L-serine Transmembrane Transporter Activity L-serine Transport Protein Binding Bleb Assembly Serine Transport Vesicle Fusion	Membrane Plasma Membrane Positive Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Life Cycle Protein Binding Mitochondrial Outer Membrane Permeabilization Mitochondrial Protein Catabolic Process Cytokine Receptor Activity External Side Of Plasma Membrane
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