TLCD4 and CYP4F22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLCD4	CYP4F22
Description		TLC domain containing 4	cytochrome P450 family 4 subfamily F member 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding
	Biological Process	Lipid Homeostasis	Lipid Metabolic Process Icosanoid Metabolic Process Ceramide Biosynthetic Process
Pathways			Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Defective CYP4F22 causes ARCI5
Drugs
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Lymphocyte count ( 32888494)
Interacting Genes		72 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CFTR CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC41A1 SLC67A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4	4 interacting genes: AQP6 MSMO1 REEP2 TLCD4
Entrez ID		148534	126410
HPRD ID		08110	08256
Ensembl ID		ENSG00000152078	ENSG00000171954
Uniprot IDs		Q96MV1	Q6NT55
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Steroid Biosynthetic Process Membrane Fusion Serine Import Into Mitochondrion Lipid Metabolic Process Sterol Metabolic Process Cholesterol Transport Establishment Of Protein Localization Sterol Transport Membrane Organization Organic Cation Transport Import Into The Mitochondrion Protein Transport L-serine Transmembrane Transporter Activity L-serine Transport Protein Binding Bleb Assembly Serine Transport Vesicle Fusion	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Taste Receptor Binding Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport C-4 Methylsterol Oxidase Activity Protein Transport Into Membrane Raft Sensory Perception Of Sweet Taste Sensory Perception Of Bitter Taste Monoatomic Anion Channel Activity Ammonium Channel Activity Renal Water Transport Protein Localization To Membrane Raft Ammonium Transmembrane Transport Endoplasmic Reticulum Water Channel Activity Carbon Dioxide Transport Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network One-carbon Compound Transport Water Transport Sensory Perception Of Taste Fluid Transport Cholesterol Biosynthetic Process Channel Activity Sterol Biosynthetic Process Cytoplasmic Microtubule Endoplasmic Reticulum Organization
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