TLCD4 and EMC6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLCD4	EMC6
Description		TLC domain containing 4	ER membrane protein complex subunit 6
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane EMC Complex Omegasome Membrane
	Molecular Function	Protein Binding	Protein Binding Membrane Insertase Activity
	Biological Process	Lipid Homeostasis	Autophagosome Assembly Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways
Drugs
Diseases
GWAS
Interacting Genes		72 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CFTR CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC41A1 SLC67A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4	21 interacting genes: AQP6 AQP9 CD79A CREB3 EBP ELOVL4 ERGIC3 FAM209A FFAR2 MMD MUC1 PDZK1IP1 SLC10A1 SLC10A6 SLC35H1 SLC39A2 SLC71A2 SLC7A1 TLCD4 TMEM14B TMEM237
Entrez ID		148534	83460
HPRD ID		08110	14529
Ensembl ID		ENSG00000152078	ENSG00000127774
Uniprot IDs		Q96MV1	Q9BV81
PDB IDs			6WW7 6Z3W 7ADO 7ADP 8EOI 8J0N 8J0O 8S9S 9C7V
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Steroid Biosynthetic Process Membrane Fusion Serine Import Into Mitochondrion Lipid Metabolic Process Sterol Metabolic Process Cholesterol Transport Establishment Of Protein Localization Sterol Transport Membrane Organization Organic Cation Transport Import Into The Mitochondrion Protein Transport L-serine Transmembrane Transporter Activity L-serine Transport Protein Binding Bleb Assembly Serine Transport Vesicle Fusion	Membrane Bile Acid:sodium Symporter Activity Transmembrane Transport Water Channel Activity Bile Acid And Bile Salt Transport Nitrate Transmembrane Transporter Activity One-carbon Compound Transport Fluid Transport Water Transport Channel Activity Organic Hydroxy Compound Transport Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Organic Anion Transport Positive Regulation Of Deacetylase Activity Cholesterol-5,6-oxide Hydrolase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport
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