CLEC7A and FAM3A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CLEC7A	FAM3A
Description		C-type lectin domain containing 7A	FAM3 metabolism regulating signaling molecule A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space
	Molecular Function	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Identical Protein Binding Metal Ion Binding	Carbohydrate Binding
	Biological Process	Cell Activation Response To Yeast Detection Of Yeast Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Cell Surface Pattern Recognition Receptor Signaling Pathway Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Population Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation T Cell Activation Defense Response To Protozoan Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Lymphocyte Activation Positive Regulation Of Respiratory Burst Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation Positive Regulation Of T-helper 17 Type Immune Response	Glucose Metabolic Process ATP Biosynthetic Process Mitochondrion Organization Response To Glucose Gene Expression Antifungal Humoral Response Insulin Secretion Calcium Ion Homeostasis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Antifungal Innate Immune Response
Pathways		CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS			Eosinophil count ( 32888494) Hemoglobin levels ( 26366553) Red blood cell traits ( 23446634)
Interacting Genes		48 interacting genes: ADAM33 AIP ARL13B ASGR2 BNIP3 BNIP3L C14orf180 CALM3 CD53 CD74 CFTR CTXN3 CXCL9 FAM3A FCGR1A FNDC9 GJB1 HSPD1 IFNGR2 IL1RL1 JAGN1 KLRC1 KTN1 MTIF3 NEMP1 NINJ2 NSG2 OCLN OLFM4 OPRM1 PTTG1IP RANBP9 RHOU SAR1A SEC22A SGCB SMIM3 SPINT1 SUSD3 SYNE4 TEX29 TLCD4 TMEM79 TMPRSS2 TMPRSS4 UPK2 VSIR ZFPL1	9 interacting genes: ANP32B APP CLEC7A CREB3 MAL2 MEOX2 MS4A12 PACRGL UBC
Entrez ID		64581	60343
HPRD ID		08396	06505
Ensembl ID		ENSG00000172243	ENSG00000071889
Uniprot IDs		A0A0S2Z5Q1 A0A2Z5YRT6 A0A2Z5YRU4 Q68D78 Q9BXN2	D3DWX8 P98173 Q5HY75 Q9BU27
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Positive Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Life Cycle Protein Binding Mitochondrial Outer Membrane Permeabilization Mitochondrial Protein Catabolic Process Cytokine Receptor Activity External Side Of Plasma Membrane	Regulation Of Superoxide Anion Generation Response To Yeast Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Metabolic Process Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response To Fungus Response To Fungus Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Deacetylase Activity Detection Of Yeast Detection Of Molecule Of Fungal Origin Positive Regulation Of Transport Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Roof Of Mouth Development Acetylcholine Receptor Activator Activity Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Migration Positive Regulation Of Interleukin-6 Production Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Regulation Of Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Detection Of Fungus (1->3)-beta-D-glucan Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Chemokine Production Regulation Of Interleukin-1 Production Regulation Of Locomotion Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium
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