TLCD4 and SEC22B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLCD4	SEC22B
Description		TLC domain containing 4	SEC22 homolog B, vesicle trafficking protein
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome
	Molecular Function	Protein Binding	SNAP Receptor Activity Protein Binding
	Biological Process	Lipid Homeostasis	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process Membrane Fusion Negative Regulation Of Autophagosome Assembly
Pathways			ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS			Iris color (L* coordinate) ( 30895295)
Interacting Genes		72 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CFTR CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC41A1 SLC67A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4	57 interacting genes: ABHD16A AIG1 AQP6 B3GAT3 CD79A CERS6 CLDN7 CLRN1 CPLX4 CREB3 CREB3L1 DPM3 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCER1G FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPX8 HIBADH HSD17B13 IFNGR2 JAGN1 KIR2DL3 LHFPL1 LHFPL5 LMNA MFF MGST2 MGST3 MMGT1 MRPS18B MUC1 NDUFAF2 REEP4 RELL2 RHBDD1 SERINC2 SLC10A6 SLC35H1 STX1A STX2 STX4 STX5 TLCD4 TM4SF19 TMEM132D TMEM139 TMEM167B TMEM229B TMEM86B
Entrez ID		148534	9554
HPRD ID		08110	04939
Ensembl ID		ENSG00000152078	ENSG00000265808
Uniprot IDs		Q96MV1	O75396
PDB IDs			2NUP 2NUT 3EGD 3EGX 8HR0
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Steroid Biosynthetic Process Membrane Fusion Serine Import Into Mitochondrion Lipid Metabolic Process Sterol Metabolic Process Cholesterol Transport Establishment Of Protein Localization Sterol Transport Membrane Organization Organic Cation Transport Import Into The Mitochondrion Protein Transport L-serine Transmembrane Transporter Activity L-serine Transport Protein Binding Bleb Assembly Serine Transport Vesicle Fusion	Membrane Endoplasmic Reticulum Membrane SNARE Complex SNARE Binding SNAP Receptor Activity Exocytosis Endoplasmic Reticulum Protein Binding Positive Regulation Of Regulated Secretory Pathway Connexin Complex Gap Junction Channel Activity Secretion By Cell Vesicle Docking Glutathione Peroxidase Activity Gap Junction Leukotriene-C4 Synthase Activity Cornified Envelope Assembly Organelle Localization By Membrane Tethering Gap Junction-mediated Intercellular Transport Positive Regulation Of Exocytosis Membrane Docking Secretion Vesicle Fusion Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Organelle Membrane Fusion Intercellular Transport SNARE Complex Assembly Lipid Metabolic Process Regulation Of Regulated Secretory Pathway Membrane Assembly Organelle Fusion Regulation Of Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
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