CLEC7A and HSPD1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CLEC7A	HSPD1
Gene Name		C-type lectin domain family 7, member A	heat shock 60kDa protein 1 (chaperonin)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Coated Pit Cell Surface Membrane Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Coated Vesicle Secretory Granule Protein Complex Lipopolysaccharide Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Signaling Pattern Recognition Receptor Activity Carbohydrate Binding MHC Protein Binding Metal Ion Binding	Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Phagocytosis, Recognition Inflammatory Response Cell Recognition Carbohydrate Mediated Signaling T Cell Activation Defense Response To Protozoan Innate Immune Response	B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Viral Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation
Pathways			Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ADAM33 AIP BNIP3 BNIP3L CALM3 FAM3A HSPD1 IL1RL1 JAGN1 KTN1 NINJ2 OCLN PTTG1IP RANBP9 SMIM3 SYNE4 TMEM79 TMPRSS4	40 interactors: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CLEC7A CLU DHFR ERG FHIT HIST2H2BE HSPE1 ITGA3 ITGB1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LRRK2 LZTS2 MAPK6 NOTCH2NL NR3C1 PLG PPP2R1A PPP2R1B PRKACA PRNP RASA1 RGS20 SAMD3 SIRT3 SUMO4 TLR1 TMCC2 YWHAG
Entrez ID		64581	3329
HPRD ID		08396	00318
Ensembl ID		ENSG00000172243	ENSG00000144381
Uniprot IDs		Q68D78 Q9BXN2	P10809
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrial Protein Catabolic Process Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Macrophage Activation Establishment Of Localization In Cell Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Cellular Localization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrion Organization Regulation Of Macrophage Activation Mitochondrial Transport Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Protein Maturation Programmed Cell Death Cell Death Death Transport B Cell Cytokine Production Interleukin-33-mediated Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway Isotype Switching To IgG Isotypes Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Mitochondrial Membrane Organization Apoptotic Mitochondrial Changes Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Interferon-gamma Production Exocytosis Establishment Of Protein Localization To Organelle Neutrophil Differentiation Cuticle Development Protein Transport Immune System Process Establishment Of Protein Localization Cornification Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Reactive Oxygen Species Metabolic Process Protein Targeting Intracellular Transport Protein Import Into Nucleus Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway Nuclear Import Apoptotic Process Autophagic Cell Death Regulation Of Mitochondrial Fusion Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of High Voltage-gated Calcium Channel Activity	Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Cell Death Regulation Of Cell Death Death Apoptotic Process Positive Regulation Of Apoptotic Process Programmed Cell Death Developmental Process Response To Organic Substance Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Response To Stimulus Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Signaling Negative Regulation Of Cellular Protein Metabolic Process Cell Communication Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Negative Regulation Of Protein Phosphorylation Regulation Of Proteolysis Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intracellular Signal Transduction Cell Differentiation Cell Cycle Process Negative Regulation Of Phosphorylation Response To Stress Mitotic Cell Cycle Phase Transition Regulation Of Protein Phosphorylation Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Regulation Of Cell Adhesion Positive Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Anatomical Structure Morphogenesis Positive Regulation Of Neuron Death Regulation Of Neuron Death Response To Organic Cyclic Compound
Tagcloud ?		amplifiable batch bioreactor chose cmv dectin destabilized dhfr flask functionality fungal glucans glycoproteins glycosylated ires lectin minimize mtx opinion pest pools prr sdectin shake stably titer titers walls zymosan	5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1
Tagcloud (Difference) ?		amplifiable batch bioreactor chose cmv dectin destabilized dhfr flask functionality fungal glucans glycoproteins glycosylated ires lectin minimize mtx opinion pest pools prr sdectin shake stably titer titers walls zymosan	5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1
Tagcloud (Intersection) ?