CLEC7A and OCLN

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CLEC7A	OCLN
Gene Name		C-type lectin domain family 7, member A	occludin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Cytosol Plasma Membrane Cell-cell Junction Tight Junction Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Endocytic Vesicle Cytoplasmic Vesicle
	Molecular Function	Signaling Pattern Recognition Receptor Activity Carbohydrate Binding MHC Protein Binding Metal Ion Binding	Structural Molecule Activity Protein Binding Thiopurine S-methyltransferase Activity Protein Domain Specific Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Phagocytosis, Recognition Inflammatory Response Cell Recognition Carbohydrate Mediated Signaling T Cell Activation Defense Response To Protozoan Innate Immune Response	Protein Complex Assembly Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Methylation Cell-cell Junction Organization S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Tight Junction Assembly
Pathways			Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ADAM33 AIP BNIP3 BNIP3L CALM3 FAM3A HSPD1 IL1RL1 JAGN1 KTN1 NINJ2 OCLN PTTG1IP RANBP9 SMIM3 SYNE4 TMEM79 TMPRSS4	4 interactors: CLEC7A SYNE4 TJP2 TNFAIP3
Entrez ID		64581	100506658
HPRD ID		08396
Ensembl ID		ENSG00000172243	ENSG00000197822
Uniprot IDs		Q68D78 Q9BXN2	A8K3T2 Q16625
PDB IDs			1WPA 1XAW 3G7C
Enriched GO Terms of Interacting Partners?		Mitochondrial Protein Catabolic Process Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Macrophage Activation Establishment Of Localization In Cell Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Cellular Localization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrion Organization Regulation Of Macrophage Activation Mitochondrial Transport Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Protein Maturation Programmed Cell Death Cell Death Death Transport B Cell Cytokine Production Interleukin-33-mediated Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway Isotype Switching To IgG Isotypes Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Mitochondrial Membrane Organization Apoptotic Mitochondrial Changes Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Interferon-gamma Production Exocytosis Establishment Of Protein Localization To Organelle Neutrophil Differentiation Cuticle Development Protein Transport Immune System Process Establishment Of Protein Localization Cornification Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Reactive Oxygen Species Metabolic Process Protein Targeting Intracellular Transport Protein Import Into Nucleus Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway Nuclear Import Apoptotic Process Autophagic Cell Death Regulation Of Mitochondrial Fusion Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of High Voltage-gated Calcium Channel Activity	Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of CD40 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Osteoclast Proliferation Tolerance Induction To Lipopolysaccharide Positive Regulation Of Innate Immune Response Carbohydrate Mediated Signaling Regulation Of CD40 Signaling Pathway Regulation Of Vascular Wound Healing Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Chronic Inflammatory Response Regulation Of Innate Immune Response Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway B-1 B Cell Homeostasis Establishment Of Endothelial Intestinal Barrier Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Tolerance Induction Regulation Of Hepatocyte Proliferation Protein K11-linked Deubiquitination Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Establishment Of Monopolar Cell Polarity Regulation Of Chronic Inflammatory Response Inflammatory Response Negative Regulation Of Bone Resorption Negative Regulation Of Interleukin-1 Beta Production Regulation Of Germinal Center Formation Immune Response-regulating Signaling Pathway Negative Regulation Of Bone Remodeling Negative Regulation Of Tissue Remodeling Response To Muramyl Dipeptide Protein K48-linked Deubiquitination Phagocytosis, Recognition Protein K63-linked Deubiquitination Establishment Of Epithelial Cell Polarity Epithelial Cell Differentiation Negative Regulation Of Interleukin-2 Production Regulation Of Lipopolysaccharide-mediated Signaling Pathway Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Protein Localization To Vacuole Defense Response To Protozoan
Tagcloud ?		amplifiable batch bioreactor chose cmv dectin destabilized dhfr flask functionality fungal glucans glycoproteins glycosylated ires lectin minimize mtx opinion pest pools prr sdectin shake stably titer titers walls zymosan	accordingly ap4 besides bioinformatic cadherin cd44 cdh1 claudins concomitantly conversely crc displays ectopic emt fn1 helix hundreds imply invasion lgr5 mesenchymal myc presumably repressed snail stemness tfap4 transition vim
Tagcloud (Difference) ?		amplifiable batch bioreactor chose cmv dectin destabilized dhfr flask functionality fungal glucans glycoproteins glycosylated ires lectin minimize mtx opinion pest pools prr sdectin shake stably titer titers walls zymosan	accordingly ap4 besides bioinformatic cadherin cd44 cdh1 claudins concomitantly conversely crc displays ectopic emt fn1 helix hundreds imply invasion lgr5 mesenchymal myc presumably repressed snail stemness tfap4 transition vim
Tagcloud (Intersection) ?