TLCD4 and ADGRB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLCD4	ADGRB3
Description		TLC domain containing 4	adhesion G protein-coupled receptor B3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Plasma Membrane Membrane Synaptic Cleft Postsynapse Postsynaptic Density Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity GTPase Activator Activity Protein Binding
	Biological Process	Lipid Homeostasis	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Myoblast Fusion Neuron Remodeling Negative Regulation Of Angiogenesis Cell Differentiation Regulation Of Dendrite Morphogenesis Positive Regulation Of Synapse Assembly Motor Learning Regulation Of Synapse Maturation Maintenance Of Synapse Structure Regulation Of Synapse Pruning
Pathways
Drugs
Diseases
GWAS			Adiponectin levels ( 33562295) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Negative urgency ( 30718321) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)
Interacting Genes		72 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CFTR CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC41A1 SLC67A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4	9 interacting genes: C1QL3 DSCR9 ELMO1 GPATCH11 GPR37L1 MUC1 SLC7A1 SNTA1 TLCD4
Entrez ID		148534	577
HPRD ID		08110	04064
Ensembl ID		ENSG00000152078	ENSG00000135298
Uniprot IDs		Q96MV1	O60242
PDB IDs			4DLO
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Steroid Biosynthetic Process Membrane Fusion Serine Import Into Mitochondrion Lipid Metabolic Process Sterol Metabolic Process Cholesterol Transport Establishment Of Protein Localization Sterol Transport Membrane Organization Organic Cation Transport Import Into The Mitochondrion Protein Transport L-serine Transmembrane Transporter Activity L-serine Transport Protein Binding Bleb Assembly Serine Transport Vesicle Fusion
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