CLEC7A and IL1RL1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CLEC7A	IL1RL1
Gene Name		C-type lectin domain family 7, member A	interleukin 1 receptor-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Matrix
	Molecular Function	Signaling Pattern Recognition Receptor Activity Carbohydrate Binding MHC Protein Binding Metal Ion Binding	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Receptor Signaling Protein Activity Protein Binding
	Biological Process	Pattern Recognition Receptor Signaling Pathway Phagocytosis, Recognition Inflammatory Response Cell Recognition Carbohydrate Mediated Signaling T Cell Activation Defense Response To Protozoan Innate Immune Response	Negative Regulation Of T-helper 1 Type Immune Response Immune Response Signal Transduction Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-5 Production Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Inflammatory Response Positive Regulation Of Chemokine Secretion
Pathways
Drugs
Diseases
GWAS			Asthma ( 23028483 21804549) Atopic dermatitis ( 23042114) Celiac disease ( 20190752 18311140) Crohn's disease ( 21102463) Eosinophil counts ( 19198610) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		18 interactors: ADAM33 AIP BNIP3 BNIP3L CALM3 FAM3A HSPD1 IL1RL1 JAGN1 KTN1 NINJ2 OCLN PTTG1IP RANBP9 SMIM3 SYNE4 TMEM79 TMPRSS4	6 interactors: APP CLEC7A IL33 MYD88 TIRAP TMED1
Entrez ID		64581	9173
HPRD ID		08396	03123
Ensembl ID		ENSG00000172243	ENSG00000115602
Uniprot IDs		Q68D78 Q9BXN2	B4E0I3 Q01638
PDB IDs			4KC3
Enriched GO Terms of Interacting Partners?		Mitochondrial Protein Catabolic Process Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Macrophage Activation Establishment Of Localization In Cell Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Cellular Localization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrion Organization Regulation Of Macrophage Activation Mitochondrial Transport Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Protein Maturation Programmed Cell Death Cell Death Death Transport B Cell Cytokine Production Interleukin-33-mediated Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway Isotype Switching To IgG Isotypes Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Mitochondrial Membrane Organization Apoptotic Mitochondrial Changes Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Interferon-gamma Production Exocytosis Establishment Of Protein Localization To Organelle Neutrophil Differentiation Cuticle Development Protein Transport Immune System Process Establishment Of Protein Localization Cornification Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Reactive Oxygen Species Metabolic Process Protein Targeting Intracellular Transport Protein Import Into Nucleus Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway Nuclear Import Apoptotic Process Autophagic Cell Death Regulation Of Mitochondrial Fusion Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of High Voltage-gated Calcium Channel Activity	Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Regulation Of Interleukin-6 Production 3'-UTR-mediated MRNA Stabilization Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Immune Response Positive Regulation Of Innate Immune Response MRNA Stabilization Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Protein Metabolic Process Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Signal Transduction Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Posttranscriptional Regulation Of Gene Expression Defense Response Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Toll-like Receptor 4 Signaling Pathway Signaling Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cytokine Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Negative Regulation Of Immunoglobulin Secretion TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway
Tagcloud ?		amplifiable batch bioreactor chose cmv dectin destabilized dhfr flask functionality fungal glucans glycoproteins glycosylated ires lectin minimize mtx opinion pest pools prr sdectin shake stably titer titers walls zymosan	acetylated basophilic basophils chip clarify coexpression dendritic emsa encodes eosinophils gata gata1 gata2 introduced killer ku812 lad2 lineages mast modulator motifs possess repressed sirna sirnas st2 start th2 transactivated
Tagcloud (Difference) ?		amplifiable batch bioreactor chose cmv dectin destabilized dhfr flask functionality fungal glucans glycoproteins glycosylated ires lectin minimize mtx opinion pest pools prr sdectin shake stably titer titers walls zymosan	acetylated basophilic basophils chip clarify coexpression dendritic emsa encodes eosinophils gata gata1 gata2 introduced killer ku812 lad2 lineages mast modulator motifs possess repressed sirna sirnas st2 start th2 transactivated
Tagcloud (Intersection) ?