TLCD4 and SFXN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TLCD4	SFXN1
Description		TLC domain containing 4	sideroflexin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Monoatomic Ion Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Lipid Homeostasis	One-carbon Metabolic Process Monoatomic Ion Transport Iron Ion Transport Amino Acid Transport L-alanine Transport L-serine Transport Erythrocyte Differentiation Monoatomic Ion Transmembrane Transport Transmembrane Transport Serine Import Into Mitochondrion
Pathways
Drugs
Diseases
GWAS			Height ( 28552196) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Night sleep phenotypes ( 27126917)
Interacting Genes		72 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CFTR CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC41A1 SLC67A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4	14 interacting genes: AQP6 CIDEB FCER1G HSD17B13 MMD PGRMC2 SCN3B SLC10A1 SLC10A6 SLC16A7 STOM TLCD4 TMEM14B TMX2
Entrez ID		148534	94081
HPRD ID		08110	18044
Ensembl ID		ENSG00000152078	ENSG00000164466
Uniprot IDs		Q96MV1	Q9H9B4
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Steroid Biosynthetic Process Membrane Fusion Serine Import Into Mitochondrion Lipid Metabolic Process Sterol Metabolic Process Cholesterol Transport Establishment Of Protein Localization Sterol Transport Membrane Organization Organic Cation Transport Import Into The Mitochondrion Protein Transport L-serine Transmembrane Transporter Activity L-serine Transport Protein Binding Bleb Assembly Serine Transport Vesicle Fusion	Organic Hydroxy Compound Transport Bile Acid:sodium Symporter Activity Membrane Symporter Activity Bile Acid And Bile Salt Transport Monocarboxylic Acid Transport Sodium Ion Transport Nitrate Transmembrane Transporter Activity Monoatomic Ion Transport Endoplasmic Reticulum IgE Receptor Activity Pyruvate Secondary Active Transmembrane Transporter Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Transmembrane Transport Tertiary Granule Membrane Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Carboxylic Acid Transport Organic Acid Transport Metal Ion Transport Secondary Active Monocarboxylate Transmembrane Transporter Activity Identical Protein Binding Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity Monoatomic Cation Transport Lipid Transport Organic Anion Transport Lipid Droplet Steroid Dehydrogenase Activity Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Pyruvate Transmembrane Transporter Activity Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Plasma Membrane Lactate Transport Pyruvate Transmembrane Transport Lipid Droplet Fusion Lactate Transmembrane Transporter Activity Pyruvate Transport SA Node Cell Action Potential
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