CLEC7A and C14orf180

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLEC7A	C14orf180
Description		C-type lectin domain containing 7A	chromosome 14 open reading frame 180
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane	Plasma Membrane Membrane
	Molecular Function	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Cell Activation Response To Yeast Detection Of Yeast Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Cell Surface Pattern Recognition Receptor Signaling Pathway Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Population Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation T Cell Activation Defense Response To Protozoan Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Lymphocyte Activation Positive Regulation Of Respiratory Burst Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation Positive Regulation Of T-helper 17 Type Immune Response
Pathways		CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Rheumatoid arthritis ( 30891314)
Interacting Genes		48 interacting genes: ADAM33 AIP ARL13B ASGR2 BNIP3 BNIP3L C14orf180 CALM3 CD53 CD74 CFTR CTXN3 CXCL9 FAM3A FCGR1A FNDC9 GJB1 HSPD1 IFNGR2 IL1RL1 JAGN1 KLRC1 KTN1 MTIF3 NEMP1 NINJ2 NSG2 OCLN OLFM4 OPRM1 PTTG1IP RANBP9 RHOU SAR1A SEC22A SGCB SMIM3 SPINT1 SUSD3 SYNE4 TEX29 TLCD4 TMEM79 TMPRSS2 TMPRSS4 UPK2 VSIR ZFPL1	47 interacting genes: AQP3 AQP6 ARL13B ASZ1 BIK CD74 CD79A CISD2 CLEC7A CPLX4 CYBC1 EBAG9 ERGIC3 FAM174A FAM209A GPR152 GPRC5D GPX8 HAS3 KASH5 KCNJ6 LHFPL5 LIME1 MFF MGST3 MUC1 NCR3LG1 PDZK1IP1 PPP1CB PPP1CC REEP4 SAR1A SLC10A6 SLC35H1 SLC71A2 TEX29 TIMMDC1 TM4SF19 TMEM106C TMEM14B TMEM167B TMEM207 TMEM31 TMEM51 TMEM80 VSIR ZDHHC15
Entrez ID		64581	400258
HPRD ID		08396	17383
Ensembl ID		ENSG00000172243	ENSG00000184601
Uniprot IDs		A0A0S2Z5Q1 A0A2Z5YRT6 A0A2Z5YRU4 Q68D78 Q9BXN2	B4DN93 J3KNP8 Q8N912
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Positive Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Life Cycle Protein Binding Mitochondrial Outer Membrane Permeabilization Mitochondrial Protein Catabolic Process Cytokine Receptor Activity External Side Of Plasma Membrane	Membrane Protein Binding B Cell Receptor Complex PTW/PP1 Phosphatase Complex
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